Our Insights
We’ve built this living repository to share our expertise on the microbiome and investigational fecal microbiota transplantation (FMT). This digital library contains white papers and academic publications describing the knowledge gleaned from treating more than 64,000 patients with investigational FMT preparations and collaborating on more than 40 clinical trials across 30 disease indications.
Our Publication Highlights
An omics-based framework for assessing the health risk of antimicrobial resistance genes
- Research from our expanded global mission & new flagship program
Use of Fecal Microbial Transplantation for Immune Checkpoint Inhibitor Colitis
-OpenBiome partners with clinicians to investigate FMT as a treatment for a variety of diseases
Fecal Microbiota Transplantation: An Introduction to FMT, its History, and Therapeutic Potential
-An introduction to FMT from our collection of White Papers
New & Noteworthy
2023
Fecal Microbiota Transplantation For Clostridioides Difficile Infection In Immunocompromised Pediatric Patients Opens a new window
Conover KR, Absah I, Ballal S, Brumbaugh D, Cho S, Cardenas MC, Knackstedt ED, Goyal A, Jensen MK, Kaplan JL, Kellermayer R, Kociolek LK, Michail S, Oliva-Hemker M, Reed AW, Weatherly M, Kahn SA, Nicholson MR. FECAL MICROBIOTA TRANSPLANTATION FOR CLOSTRIDIOIDES DIFFICILE INFECTION IN IMMUNOCOMPROMISED PEDIATRIC PATIENTS. J Pediatr Gastroenterol Nutr. 2023 Jan 31. doi: 10.1097/MPG.0000000000003714. Epub ahead of print. PMID: 36720105.
2023
Fecal Microbiota Transplantation Across the Lifespan: Balancing Efficacy, Safety, and Innovation Opens a new window
Gulati AS, Nicholson MR, Khoruts A, Kahn SA. Fecal Microbiota Transplantation Across the Lifespan: Balancing Efficacy, Safety, and Innovation. Am J Gastroenterol. 2023 Jan 25. doi: 10.14309/ajg.0000000000002167. Epub ahead of print. PMID: 36580630.
2022
Impact of Fecal Microbiota Transplantation on Gut Bacterial Bile Acid Metabolism in Humans Opens a new window
Bustamante JM, Dawson T, Loeffler C, Marfori Z, Marchesi JR, Mullish BH, Thompson CC, Crandall KA, Rahnavard A, Allegretti JR, Cummings BP. Impact of Fecal Microbiota Transplantation on Gut Bacterial Bile Acid Metabolism in Humans. Nutrients. 2022 Dec 7;14(24):5200. doi: 10.3390/nu14245200. PMID: 36558359; PMCID: PMC9785599.
2016
Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer Opens a new window
van Beurden, Y.H., van Gils, T., van Gils, N.A., Kassam, Z., Mulder, C.J., Aparicio-Pagés, N. (2016) Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer. J Gastrointestin Liver Dis., 25(3), 385-8.
2018
Fecal Microbiota Transplantation Improves Gastrointestinal Graft-Versus-Host Disease and Restores the Microbiome: A Pediatric Experience Opens a new window
Wong, W. F., Budree, S., Osman, M., Panchal, P., Kassam, Z., Corkins, M. R., ... & Maron, G. M. (2018). Tu1882-Fecal Microbiota Transplantation Improves Gastrointestinal Graft-Versus-Host Disease and Restores the Microbiome: A Pediatric Experience. Gastroenterology, 154(6), S-1046.
2018
Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort Opens a new window
Gurry, T., HST Microbiome Consortium*, Gibbons, S. M., Nguyen, L., Kearney, S. M., Ananthakrishnan, A., Jiang, X., Duvallet, C., Kassam, Z., … Alm, E. J. (2018). Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort. Scientific Reports, 8(1), 12699. doi:10.1038/s41598-018-30783-1
2018
HIV-exposure, early life feeding practices and delivery mode impacts on faecal bacterial profiles in a South African birth cohort Opens a new window
Claassen-Weitz, S., Gardner-Lubbe, S., Nicol, P., Botha, G., Mounaud, S., Shankar, J., ... & Nicol, M. P. (2018). HIV-exposure, early life feeding practices and delivery mode impacts on faecal bacterial profiles in a South African birth cohort. Scientific Reports, 8(1), 5078.
2018
Intestinal Microbial and Metabolic Alterations Following Successful Fecal Microbiota Transplant for D-Lactic Acidosis Opens a new window
Bulik-Sullivan, E. C., Roy, S., Elliott, R. J., Kassam, Z., Lichtman, S. N., Carroll, I. M., & Gulati, A. S. (2018). Intestinal microbial and metabolic alterations following successful fecal microbiota transplant for D-lactic acidosis. Journal of Pediatric Gastroenterology and Nutrition, 67(4), 483-487.
2019
Microbiome predictors of dysbiosis and VRE decolonization in patients with recurrent C. difficile infections in a multi-center retrospective study Opens a new window
Santiago, M., Eysenbach, L., Allegretti, J., Aroniadis, O., J. Brandt, L., & Fischer, M. et al. (2019). Microbiome predictors of dysbiosis and VRE decolonization in patients with recurrent C. difficile infections in a multi-center retrospective study. AIMS Microbiology, 5(1), 1-18. doi:10.3934/microbiol.2019.1.1
2019
Successful Treatment of Fulminant Clostridioides difficile Infection with Emergent Fecal Microbiota Transplantation in a Patient with Acute Myeloid Leukemia and Prolonged, Severe Neutropenia Opens a new window
Lee, M., Ramakrishna, B., Moss, A., Gold, H., & Branch‐Elliman, W. (2019). Successful Treatment of Fulminant Clostridioides difficile Infection with Emergent Fecal Microbiota Transplantation in a Patient with Acute Myeloid Leukemia and Prolonged, Severe Neutropenia. Transplant Infectious Disease. doi:10.1111/tid.13216
2019
Fulminant Clostridium difficile Infection Cured by Fecal Microbiota Transplantation in a Bone Marrow Transplant Recipient With Critical Neutropenia Opens a new window
Krajicek, E., Bohm, M., Sagi, S., & Fischer, M. (2019). Fulminant Clostridium difficile Infection Cured by Fecal Microbiota Transplantation in a Bone Marrow Transplant Recipient With Critical Neutropenia. ACG Case Reports Journal, 6(8), e00198. doi:10.14309/crj.0000000000000198
2019
Rapid Detection of Clostridium difficile Toxins in Stool by Raman Spectroscopy Opens a new window
Koya, S., Yurgelevic, S., Brusatori, M., Huang, C., Diebel, L., & Auner, G. (2019). Rapid Detection of Clostridium difficile Toxins in Stool by Raman Spectroscopy. Journal Of Surgical Research, 244, 111-116. doi:10.1016/j.jss.2019.06.039
2019
Framework for rational donor selection in fecal microbiota transplant clinical trials Opens a new window
Duvallet, C., Zellmer, C., Panchal, P., Budree, S., Osman, M., & Alm, E. (2019). Framework for rational donor selection in fecal microbiota transplant clinical trials. doi:10.1101/19000307
2019
Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial Opens a new window
Aroniadis, O., Brandt, L., Oneto, C., Feuerstadt, P., Sherman, A., & Wolkoff, A. et al. (2019). Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial. The Lancet Gastroenterology & Hepatology. doi:10.1016/s2468-1253(19)30198-0
2020
Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: a retrospective cohort study Opens a new window
Vendrik, K., Terveer, E., Kuijper, E., Nooij, S., Boeije-Koppenol, E., & Sanders, I. et al. (2020). Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: a retrospective cohort study. The Lancet Infectious Diseases. doi: 10.1016/s1473-3099(20)30473-4
2020
Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade Opens a new window
SahBandar, I., Chew, G., Corley, M., Pang, A., Tsai, N., & Hanks, N. et al. (2020). Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade. AIDS, 34(10), 1451-1460. doi: 10.1097/qad.0000000000002557
2020
Modelling donor screening strategies to reduce the risk of SARS-CoV-2 transmission via fecal microbiota transplantation Opens a new window
Olesen, S., Zaman, A., Osman, M., & Ramakrishna, B. (2020). Modelling donor screening strategies to reduce the risk of SARS-CoV-2 transmission via fecal microbiota transplantation. Open Forum Infectious Diseases. doi: 10.1093/ofid/ofaa499
2020
Global disparities in faecal microbiota transplantation research Opens a new window
Olesen, S., Panchal, P., Chen, J., Budree, S., & Osman, M. (2020). Global disparities in faecal microbiota transplantation research. The Lancet Gastroenterology & Hepatology, 5(3), 241. doi:10.1016/s2468-1253(19)30452-2
2020
Gut microbial dysbiosis in individuals with Sjögren’s syndrome Opens a new window
Mendez, R., Watane, A., Farhangi, M., Cavuoto, K., Leith, T., & Budree, S. et al. (2020). Gut microbial dysbiosis in individuals with Sjögren’s syndrome. Microbial Cell Factories, 19(1). doi:10.1186/s12934-020-01348-7
2020
Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro Opens a new window
Mahalak, K., Firrman, J., Lee, J., Bittinger, K., Nunez, A., Mattei, L., Zhang, H., Fett, B., Bobokalonov, J., Arango-Argoty, G., Zhang, G., Zhang, G., Liu, Lin. (2020) Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro. PLONE ONE. 15(6): e0234046. https://doi.org/10.1371/journal. pone.0234046
2020
The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients Opens a new window
Lötstedt B, Boyer D, Visner G, Freiberger D, Lurie M, Kane M, DiFilippo C, Lundeberg J, Narvaez-Rivas M, Setchell K, Alm E, Rosen R. The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients. J Heart Lung Transplant. 2020 Dec 5:S1053-2498(20)31860-X. doi: 10.1016/j.healun.2020.11.013. Epub ahead of print. PMID: 33349521.
2020
Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel Opens a new window
Ianiro, G., Mullish, B., Kelly, C., Sokol, H., Kassam, Z., & Ng, S. et al. (2020). Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel. The Lancet Gastroenterology & Hepatology. doi:10.1016/s2468-1253(20)30082-0
2020
Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic Opens a new window
Ianiro, G., Mullish, B., Kelly, C., Kassam, Z., Kuijper, E., & Ng, S. et al. (2020). Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic. Gut, gutjnl-2020-321829. doi: 10.1136/gutjnl-2020-321829
2020
Beyond fecal microbiota transplantation: Developing drugs from the microbiome Opens a new window
Gerardin Y, Timberlake S, Allegretti JR, Smith MB, Kassam Z. Beyond fecal microbiota transplantation: Developing drugs from the microbiome. J Infect Dis. 2020 Dec 17:jiaa700. doi: 10.1093/infdis/jiaa700. Epub ahead of print. PMID: 33330910.
2020
Use of Fecal Microbial Transplantation for Immune Checkpoint Inhibitor Colitis Opens a new window
Fasanello, M., Robillard, K., Boland, P., Bain, A., & Kanehira, K. (2020). Use of Fecal Microbial Transplantation for Immune Checkpoint Inhibitor Colitis. ACG Case Reports Journal, 7(4), e00360. doi: 10.14309/crj.0000000000000360
2021
An omics-based framework for assessing the health risk of antimicrobial resistance genes Opens a new window
Zhang AN, Gaston JM, Dai CL, Zhao S, Poyet M, Groussin M, Yin X, Li LG, van Loosdrecht MCM, Topp E, Gillings MR, Hanage WP, Tiedje JM, Moniz K, Alm EJ, Zhang T. An omics-based framework for assessing the health risk of antimicrobial resistance genes. Nat Commun. 2021 Aug 6;12(1):4765. doi: 10.1038/s41467-021-25096-3. PMID: 34362925.
2021
Carriage rates of multidrug-resistant organisms among prospective stool donors Opens a new window
Zaman A, Qazi T, Pai P, Peters P, Nicolaysen S, Olesen SW. Carriage rates of multidrug-resistant organisms among prospective stool donors. Lancet Infect Dis. 2021 Apr;21(4):454-455. doi: 10.1016/S1473-3099(21)00091-8. PMID: 33773125.
2021
Fecal microbiota transplantation in HIV: A pilot placebo-controlled study Opens a new window
Serrano-Villar S, Talavera-Rodríguez A, Gosalbes MJ, Madrid N, Pérez-Molina JA, Elliott RJ, Navia B, Lanza VF, Vallejo A, Osman M, Dronda F, Budree S, Zamora J, Gutiérrez C, Manzano M, Vivancos MJ, Ron R, Martínez-Sanz J, Herrera S, Ansa U, Moya A, Moreno S. Fecal microbiota transplantation in HIV: A pilot placebo-controlled study. Nat Commun. 2021 Feb 18;12(1):1139. doi: 10.1038/s41467-021-21472-1. PMID: 33602945.
2021
16S rRNA sequencing of samples from universal stool bank donors Opens a new window
Santiago M, Olesen SW. 16S rRNA sequencing of samples from universal stool bank donors. BMC Res Notes. 2021 Mar 23;14(1):108. doi: 10.1186/s13104-021-05520-z. PMID: 33757553; PMCID: PMC7988957
2021
SARS-CoV-2 vaccines and donor recruitment for FMT Opens a new window
Ianiro G, Mullish BH, Hvas CL, Segal JP, Kuijper EJ, Costello SP, Kelly CR, Allegretti JR, Fischer M, Iqbal TH, Satokari R, Kao D, van Prehn J, Ng SC, Bibbò S, Baunwall SMD, Quraishi MN, Sokol H, Zhang F, Keller J, Masucci L, Quaranta G, Kassam Z, Sanguinetti M, Tilg H, Gasbarrini A, Cammarota G. SARS-CoV-2 vaccines and donor recruitment for FMT. Lancet Gastroenterol Hepatol. 2021 Feb 8:S2468-1253(21)00032-7. doi: 10.1016/S2468-1253(21)00032-7. Epub ahead of print. PMID: 33571456.
2021
Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation Opens a new window
Fujimoto K, Kimura Y, Allegretti JR, Yamamoto M, Zhang YZ, Katayama K, Tremmel G, Kawaguchi Y, Shimohigoshi M, Hayashi T, Uematsu M, Yamaguchi K, Furukawa Y, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation. Gastroenterology. 2021 Feb 9:S0016-5085(21)00400-5. doi: 10.1053/j.gastro.2021.02.013. Epub ahead of print. PMID: 33577875.
2021
Progressive Shifts in the Gut Microbiome Reflect Prediabetes and Diabetes Development in a Treatment-Naive Mexican Cohort Opens a new window
Diener, C., Reyes-Escogido, M., Jimenez-Ceja, L., Matus, M., Gomez-Navarro, C., & Chu, N. et al. (2021). Progressive Shifts in the Gut Microbiome Reflect Prediabetes and Diabetes Development in a Treatment-Naive Mexican Cohort. Frontiers In Endocrinology, 11. doi: 10.3389/fendo.2020.602326
2021
Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes Opens a new window
Aggarwala V, Mogno I, Li Z, Yang C, Britton GJ, Chen-Liaw A, Mitcham J, Bongers G, Gevers D, Clemente JC, Colombel JF, Grinspan A, Faith J. Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes. Nat Microbiol. 2021 Oct;6(10):1309-1318. doi: 10.1038/s41564-021-00966-0. Epub 2021 Sep 27. PMID: 34580445.
2022
Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye Opens a new window
Watane A, Cavuoto KM, Rojas M, Dermer H, Day JO, Banerjee S, Galor A. Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye. Am J Ophthalmol. 2022 Jan;233:90-100. doi: 10.1016/j.ajo.2021.06.022. Epub 2021 Jun 30. PMID: 34214453; PMCID: PMC8678170.
2022
Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report Opens a new window
Beglinger C, Borgwardt S, Raes J, Schmidt A, Lang UE. Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report. Front Psychiatry. 2022 Feb 17;13:815422. doi: 10.3389/fpsyt.2022.815422. PMID: 35250668; PMCID: PMC8891755.
2017
Does fecal microbiota transplantation from an obese donor lead to weight gain? A case series of 70 recipients Opens a new window
Fischer, M., Sipe, B., Torbeck, M., Xu, H., Kassam, Z., & Allegretti, J. R. (2017). Does fecal microbiota transplantation from an obese donor lead to weight gain? A case series of 70 recipients. Gastroenterology, 152(5), S1004.
2019
Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients Opens a new window
Allegretti, J., Kassam, Z., Mullish, B., Chiang, A., Carrellas, M., & Hurtado, J. et al. (2019). Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients. Clinical Gastroenterology And Hepatology. doi:10.1016/j.cgh.2019.07.006
2020
Fecal microbiota transplantation improves metabolic syndrome parameters: systematic review with meta-analysis based on randomized clinical trials Opens a new window
Proença IM, Allegretti JR, Bernardo WM, de Moura DTH, Ponte Neto AM, Matsubayashi CO, Flor MM, Kotinda APST, de Moura EGH. Fecal microbiota transplantation improves metabolic syndrome parameters: systematic review with meta-analysis based on randomized clinical trials. Nutr Res. 2020 Nov;83:1-14. doi: 10.1016/j.nutres.2020.06.018. Epub 2020 Jul 3. PMID: 32987284.
2021
Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity Opens a new window
Allegretti JR, Kassam Z, Hurtado J, Marchesi JR, Mullish BH, Chiang A, Thompson CC, Cummings BP. Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity. Hormones (Athens). 2021 Jan 9. doi: 10.1007/s42000-020-00265-z. Epub ahead of print. PMID: 33420959.
2017
The Gut Microbiome in Autoimmune Hepatitis Links to Disease Progression and is Significantly Different from Lupus and Healthy Controls Opens a new window
Kumar, V., Vieira, S. M., Ruff, W., Dehner, C., Kassam, Z., Boyer, J. L., ... & Kriegel, M. (2017, October). The Gut Microbiome in Autoimmune Hepatitis Links to Disease Progression and is Significantly Different from Lupus and Healthy Controls. HEPATOLOGY (Vol. 66, pp. 189A-189A).
2017
Fecal microbiota transplant using a precision medicine approach is safe, associated with lower hospitalization risk and improved cognitive function in recurrent hepatic encephalopathy Opens a new window
Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E., Liu, E. J., Kheradman, R., ... & Alm, E. (2017). Fecal microbiota transplant using a precision medicine approach is safe, Associated with lower hospitalization risk and improved cognitive function in recurrent hepatic encephalopathy. Gastroenterology, 152(5), S906.
2017
Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial Opens a new window
Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., ... & Williams, R. (2017). Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Hepatology.
2018
Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant Opens a new window
Bajaj, J. S., Kakiyama, G., Savage, T., Takei, H, Kassam, Z. A., Fagan, A., … & Gillevet, P. M. (2018). Antibiotic‐Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant. Hepatology, 68: 1549-1558.
2019
Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial Opens a new window
Bajaj, J., Salzman, N., Acharya, C., Sterling, R., White, M., & Gavis, E. et al. (2019). Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial. Hepatology, 70(5), 1690-1703. doi:10.1002/hep.30690
2019
Long-term Outcomes after Fecal Microbiota Transplant in Cirrhosis Opens a new window
Bajaj, JS., Fagan, A., Gavis, EA., Kassam, Z., Sikaroodi, M., Gillevet, P. (2019). Long term outcomes after Fecal Microbiota Transplant in Cirrhosis. Gastroenterology, doi: https://doi.org/10.1053/j.gastro.2019.01.033
2019
Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial Opens a new window
Allegretti, J., Kassam, Z., Carrellas, M., Mullish, B., Marchesi, J., & Pechlivanis, A. et al. (2019). Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis. The American Journal Of Gastroenterology, 1. doi:10.14309/ajg.0000000000000115
2020
Fecal Microbiota Transplantation is Safe and Effective in Patients with Clostridioides difficile Infection and Cirrhosis Opens a new window
Cheng YW, Alhaffar D, Saha S, et al. Fecal Microbiota Transplantation is Safe and Effective in Patients with Clostridioides difficile Infection and Cirrhosis [published online ahead of print, 2020 Jul 6]. Clin Gastroenterol Hepatol. 2020;S1542-3565(20)30915-0. doi:10.1016/j.cgh.2020.06.051
2020
Fecal Microbiota Transplant in Cirrhosis Reduces Gut Microbial Antibiotic Resistance Genes: Analysis of Two Trials Opens a new window
Bajaj JS, Shamsaddini A, Fagan A, Sterling RK, Gavis E, Khoruts A, Fuchs M, Lee H, Sikaroodi M, Gillevet PM. Fecal Microbiota Transplant in Cirrhosis Reduces Gut Microbial Antibiotic Resistance Genes: Analysis of Two Trials. Hepatol Commun. 2020 Nov 21;5(2):258-271. doi: 10.1002/hep4.1639. PMID: 33553973; PMCID: PMC7850310.
2020
Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial Opens a new window
Bajaj, J., Salzman, N., Acharya, C., Sterling, R., White, M., & Gavis, E. et al. (2019). Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial. Hepatology, 70(5), 1690-1703. doi: 10.1002/hep.30690
2020
Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis Opens a new window
Bajaj JS, Khoruts A. Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis. J Hepatol. 2020 May;72(5):1003-1027. doi: 10.1016/j.jhep.2020.01.017. Epub 2020 Jan 28. PMID: 32004593.
2020
A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder Opens a new window
Bajaj, J., Gavis, E., Fagan, A., Wade, J., Thacker, L., & Fuchs, M. et al. (2020). A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder. Hepatology. doi: 10.1002/hep.31496
2020
Chronic Liver Diseases and the Microbiome: Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease Opens a new window
Acharya C, Bajaj JS. Chronic Liver Diseases and the Microbiome: Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease. Gastroenterology. 2020 Nov 27:S0016-5085(20)35504-9. doi: 10.1053/j.gastro.2020.10.056. Epub ahead of print. PMID: 33253686.
2016
Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease Opens a new window
Fischer, M., Kao, D., Kelly, C., Kuchipudi, A., Jafri, S. M., Blumenkehl, M., ... & Cook, G. (2016). Fecal microbiota transplantation is safe and efficacious for recurrent or refractory Clostridium difficile infection in patients with inflammatory bowel disease. Inflammatory bowel diseases, 22(10), 2402-2409.
2017
The Risk of Inflammatory Bowel Disease Flares after Fecal Microbiota Transplantation: Systematic Review and Meta-Analysis Opens a new window
Qazi, T., Amaratunga, T., Barnes, E. L., Fischer, M., Kassam, Z., & Allegretti, J. R. (2017). The risk of inflammatory bowel disease flares after fecal microbiota transplantation: Systematic review and meta-analysis. Gut microbes, 8(6), 574-588.
2017
Fecal microbiota transplantation differentially influences the gut microbiota of Clostridium difficile infection and ileal pouch anal anastomosis patients Opens a new window
Piceno, Y. M., El-Nachef, N., Kassam, Z., Smith, M., Lynch, K., Zydek, M., ... & Lynch, S. (2017). Fecal Microbiota Transplantation Differentially Influences the Gut Microbiota of Clostridium Difficile Infection and Ileal Pouch Anal Anastomosis Patients. Gastroenterology, 152(5), S1006.
2017
Systematic Review and Meta-Analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis Opens a new window
Narula, N., Kassam, Z., Yuan, Y., Colombel, J. F., Ponsioen, C., Reinisch, W., & Moayyedi, P. (2017). Systematic review and meta-analysis: Fecal microbiota transplantation for treatment of active ulcerative colitis. Inflammatory bowel diseases, 23(10), 1702-1709.
2017
A Surgical Clostridium-associated Risk of Death Score Predicts Mortality after Colectomy for Clostridium difficile Opens a new window
Kulaylat, A. S., Kassam, Z., Hollenbeak, C. S., & Stewart Sr, D. B. (2017). A Surgical Clostridium-Associated Risk of Death Score Predicts Mortality After Colectomy for Clostridium difficile. Diseases of the Colon & Rectum, 60(12), 1285-1290.
2017
Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis Opens a new window
Jacob, V., Crawford, C., Cohen-Mekelburg, S., Viladomiu, M., Putzel, G. G., Schneider, Y., ... & Ajami, N. J. (2017). Single delivery of high-diversity fecal microbiota preparation by colonoscopy is safe and effective in increasing microbial diversity in active ulcerative colitis. Inflammatory bowel diseases, 23(6), 903-911.
2017
Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease Opens a new window
Fischer, M., Bittar, M., Papa, E., Kassam, Z., & Smith, M. (2017). Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease. Gut microbes, 8(3), 205-207.
2017
Fecal microbiota transplantation is safe and effective in chronic pouchitis patients Opens a new window
El-Nachef, N., Piceno, Y. M., Kassam, Z., Zydek, M., Ablaza, A. J., Leith, T., ... & Lynch, S. (2017). Fecal Microbiota Transplantation is Safe and Effective in Chronic Pouchitis Patients. Gastroenterology, 152(5), S1009.
2017
The role of fecal microbiota transplantation in ulcerative colitis and Crohn’s disease: results from a parallel inflammatory bowel disease cohort study Opens a new window
El-Nachef, N., Piceno, Y. M., Kassam, Z., Ablaza, A. J., Zydek, M., Lynch, K., ... & Lynch, S. (2017). The Role of Fecal Microbiota Transplantation in Ulcerative Colitis and Crohn's Disease: Results from a Parallel Inflammatory Bowel Disease Cohort Study. Gastroenterology, 152(5), S1008.
2017
Does Rifaximin prior to fecal microbiota transplantation improve clinical outcomes compared to microbiome restoration alone in ulcerative colitis? A cohort study evaluating the impact of non-absorbable antibiotic pretreatment Opens a new window
El-Nachef, N., Kassam, Z., Piceno, Y. M., Ablaza, A. J., Zydek, M., Elliott, R. J., ... & Somsouk, M. (2017). Does Rifaximin Prior to Fecal Microbiota Transplantation Improve Clinical Outcomes Compared to Microbiome Restoration Alone in Ulcerative Colitis? a Cohort Study Evaluating the Impact of Non-Absorbable Antibiotic Pretreatment. Gastroenterology, 152(5), S1008-S1009.
2017
Differences in Clinical Course, Genetics, and the Microbiome Between Familial and Sporadic Inflammatory Bowel Diseases Opens a new window
Borren, N. Z., Conway, G., Garber, J. J., Khalili, H., Budree, S., Mallick, H., ... & Ananthakrishnan, A. N. (2017). Differences in Clinical Course, Genetics, and the Microbiome Between Familial and Sporadic Inflammatory Bowel Diseases. Journal of Crohn's and Colitis, 12(5), 525-531.
2017
The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present and Future Opens a new window
Allegretti, J., Eysenbach, L. M., El-Nachef, N., Fischer, M., Kelly, C., & Kassam, Z. (2017). The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present, and Future. Inflammatory bowel diseases, 23(10), 1710-1717.
2018
Advances in mesenchymal stromal cell therapy in the management of Crohn's disease Opens a new window
Ibraheim, H., Giacomini, C., Kassam, Z., Dazzi, F., & Powell, N. (2018). Advances in mesenchymal stromal cell therapy in the management of Crohn’s disease. Expert review of Gastroenterology & Hepatology, 12(2), 141-153.
2019
Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study Opens a new window
Selvig, D., Piceno, Y., Terdiman, J., Zydek, M., Umetsu, S., & Balitzer, D. et al. (2019). Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study. Digestive Diseases And Sciences. doi:10.1007/s10620-019-05715-2
2019
Combined Endoscopic and Oral Fecal Microbiota Transplantation in Patients with Antibiotic-Dependent Pouchitis: Low Clinical Efficacy due to Low Donor Microbial Engraftment Opens a new window
Herfarth, H., Barnes, E. L., Long, M. D., Isaacs, K. L., Leith, T., Silverstein, M., … Kassam, Z. (2019). Combined Endoscopic and Oral Fecal Microbiota Transplantation in Patients with Antibiotic-Dependent Pouchitis: Low Clinical Efficacy due to Low Donor Microbial Engraftment. Inflammatory Intestinal Diseases, 1–6. doi:10.1159/000497042
2019
Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile Opens a new window
Gutin, L., Piceno, Y., Fadrosh, D., Lynch, K., Zydek, M., & Kassam, Z. et al. (2019). Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile. United European Gastroenterology Journal, 7(6), 807-814. doi:10.1177/2050640619845986
2019
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Opens a new window
Gogokhia, L., Buhrke, K., Bell, R., Hoffman, B., Brown, D., & Hanke-Gogokhia, C. et al. (2019). Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell Host & Microbe, 25(2), 285-299.e8. doi:10.1016/j.chom.2019.01.008
2020
Re-Evaluating the Evidence for Faecal Microbiota Transplantation ‘Super-Donors’ in Inflammatory Bowel Disease Opens a new window
Olesen, S., & Gerardin, Y. (2020). Re-Evaluating the Evidence for Faecal Microbiota Transplantation ‘Super-Donors’ in Inflammatory Bowel Disease. Journal Of Crohn's And Colitis, 15(3), 453-461. doi: 10.1093/ecco-jcc/jjaa170
2020
Fecal transplantation for ulcerative colitis: current evidence and future applications Opens a new window
Loris R. Lopetuso, Gianluca Ianiro, Jessica R. Allegretti, Stefano Bibbò, Antonio Gasbarrini, Franco Scaldaferri & Giovanni Cammarota (2020) Fecal transplantation for ulcerative colitis: current evidence and future applications. Expert Opinion on Biological Therapy, 20(3). DOI: 10.1080/14712598.2020.1733964
2020
Fecal Microbiota Transplantation for Ulcerative Colitis. Are We Ready for Primetime? Opens a new window
Cheng, Y., & Fischer, M. (2020). Fecal Microbiota Transplantation for Ulcerative Colitis. Are We Ready for Primetime?. Gastroenterology Clinics Of North America, 49(4), 739-752. doi: 10.1016/j.gtc.2020.08.006
2020
Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection Opens a new window
Allegretti, J., Kelly, C., Grinspan, A., Mullish, B., Kassam, Z., & Fischer, M. (2020). Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection. Gastroenterology, 159(5), 1982-1984. doi: 10.1053/j.gastro.2020.07.045
2020
Inflammatory Bowel Disease Outcomes Following Fecal Microbiota Transplantation for Recurrent C. difficile Infection Opens a new window
Allegretti JR, Kelly CR, Grinspan A, Mullish BH, Hurtado J, Carrellas M, Marcus J, Marchesi JR, McDonald JAK, Gerardin Y, Silverstein M, Pechlivanis A, Barker GF, Miguens Blanco J, Alexander JL, Gallagher KI, Pettee W, Phelps E, Nemes S, Sagi SV, Bohm M, Kassam Z, Fischer M. Inflammatory Bowel Disease Outcomes Following Fecal Microbiota Transplantation for Recurrent C. difficile Infection. Inflamm Bowel Dis. 2020 Nov 6:izaa283. doi: 10.1093/ibd/izaa283. Epub ahead of print. PMID: 33155639.
2021
Transferable IgA-coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation Opens a new window
Lima S, Gogokhia L, Viladomiu M, Chou L, Putzel G, Jin W, Pires S, Guo CJ, Gerardin Y, Crawford CV, Jacob V, Scherl E, Brown SE, Hambor J, Longman R. Transferable IgA-coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation. Gastroenterology. 2021 Oct 1:S0016-5085(21)03610-6. doi: 10.1053/j.gastro.2021.09.061. Epub ahead of print. PMID: 34606847.
2021
Fecal Microbiota Transplantation for Chronic Pouchitis: Promising Novel Therapeutic or Lost Cause? Opens a new window
Dalal RS, Allegretti JR. Fecal Microbiota Transplantation for Chronic Pouchitis: Promising Novel Therapeutic or Lost Cause? Inflamm Bowel Dis. 2021 Jan 27:izab002. doi: 10.1093/ibd/izab002. Epub ahead of print. PMID: 33501941.
2021
Diagnosis and management of Clostridioides difficile infection in patients with inflammatory bowel disease Opens a new window
Dalal RS, Allegretti JR. Diagnosis and management of Clostridioides difficile infection in patients with inflammatory bowel disease. Curr Opin Gastroenterol. 2021 Mar 3. doi: 10.1097/MOG.0000000000000739. Epub ahead of print. PMID: 33654015.
2021
Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: results of a single-center, prospective, randomized pilot study Opens a new window
Crothers JW, Chu ND, Nguyen LTT, Phillips M, Collins C, Fortner K, Del Rio-Guerra R, Lavoie B, Callas P, Velez M, Cohn A, Elliott RJ, Wong WF, Vo E, Wilcox R, Smith M, Kassam Z, Budd R, Alm EJ, Mawe GM, Moses PL. Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: results of a single-center, prospective, randomized pilot study. BMC Gastroenterol. 2021 Jul 8;21(1):281. doi: 10.1186/s12876-021-01856-9. PMID: 34238227; PMCID: PMC8268596.
2021
Fecal microbial transplant for inflammatory bowel disease Opens a new window
Claytor JD, El-Nachef N. Fecal microbial transplant for inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2020 Sep;23(5):355-360. doi: 10.1097/MCO.0000000000000676. PMID: 32618725.
2021
Fecal Microbiota Transplantation for the Treatment of Ulcerative Colitis: A Qualitative Assessment of Patient Perceptions and Experiences Opens a new window
Chauhan U, Popov J, Farbod Y, Kalantar M, Wolfe M, Moayyedi P, Marshall JK, Halder S, Kaasalainen S. Fecal Microbiota Transplantation for the Treatment of Ulcerative Colitis: A Qualitative Assessment of Patient Perceptions and Experiences. J Can Assoc Gastroenterol. 2021 Mar 26;4(6):e120-e129. doi: 10.1093/jcag/gwab007. PMID: 34877470; PMCID: PMC8643654.
2022
Effect of antibiotic pretreatment on bacterial engraftment after Fecal Microbiota Transplant (FMT) in IBS-D Opens a new window
Singh P, Alm EJ, Kelley JM, Cheng V, Smith M, Kassam Z, Nee J, Iturrino J, Lembo A. Effect of antibiotic pretreatment on bacterial engraftment after Fecal Microbiota Transplant (FMT) in IBS-D. Gut Microbes. 2022 Jan-Dec;14(1):2020067. doi: 10.1080/19490976.2021.2020067. PMID: 35014601; PMCID: PMC8757476.
2022
Dynamic Colonization of Microbes and Their Functions after Fecal Microbiota Transplantation for Inflammatory Bowel Disease Opens a new window
Chu ND, Crothers JW, Nguyen LTT, Kearney SM, Smith MB, Kassam Z, Collins C, Xavier R, Moses PL, Alm EJ. Dynamic Colonization of Microbes and Their Functions after Fecal Microbiota Transplantation for Inflammatory Bowel Disease. mBio. 2021 Aug 31;12(4):e0097521. doi: 10.1128/mBio.00975-21. Epub 2021 Jul 20. PMID: 34281401; PMCID: PMC8406238.
2017
Does fecal microbiota transplantation from an obese donor lead to weight gain? A case series of 70 recipients Opens a new window
Fischer, M., Sipe, B., Torbeck, M., Xu, H., Kassam, Z., & Allegretti, J. R. (2017). Does fecal microbiota transplantation from an obese donor lead to weight gain? A case series of 70 recipients. Gastroenterology, 152(5), S1004
2017
Stool Donor Body Mass Index Does Not Affect Recipient Weight After a Single Fecal Microbiota Transplantation for Clostridium difficile Infection Opens a new window
Fischer, M., Kao, D., Kassam, Z., Smith, J., Louie, T., Sipe, B., ... & Allegretti, J. R. (2017). Stool Donor Body Mass Index Does Not Affect Recipient Weight After a Single Fecal Microbiota Transplantation for C. difficile Infection. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association.
2017
Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease Opens a new window
Fischer, M., Bittar, M., Papa, E., Kassam, Z., & Smith, M. (2017). Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease. Gut microbes, 8(3), 205-207.
2017
Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors Opens a new window
Budree, S., Wong, W. F., Tu, E., Rao, S., Allegretti, J. R., Fischer, M., ... & Kassam, Z. (2017). Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors. Gastroenterology, 152(5), S349.
2017
The association of stool donor diet on microbial profile and clinical outcomes of fecal microbiota transplantation in clostridium difficile infection Opens a new window
Budree, S., Tu, E., Leith, T., Allegretti, J. R., Rao, S., Day, R., ... & Osman, M. (2017). The Association of Stool Donor Diet on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630-S631.
2017
The association of donor stool consistency by Bristol stool scale on microbial profile and clinical outcomes of fecal microbiota transplantation in Clostridium difficile infection Opens a new window
Budree, S., Rao, S., Allegretti, J. R., Fischer, M., Kelly, C. R., Smith, M., ... & Kassam, Z. (2017). The Association of Donor Stool Consistency by Bristol Stool Scale on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630.
2017
Donor stool processing time: the effect on the intestinal microbiome and clinical outcomes of fecal microbiota transplantation in Clostridium difficile Infection Opens a new window
Budree, S., Elliott, R. J., Rao, S., Njenga, M., Ladha, A., Allegretti, J. R., ... & Kassam, Z. (2017). Donor Stool Processing Time: The Effect on the Intestinal Microbiome and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S1006.
2017
Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial Opens a new window
Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., ... & Williams, R. (2017). Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Hepatology.
2018
Does the Donor Matter? Microbiome Sequencing to Evaluate Lower Donor Efficacy in Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection Opens a new window
Osman, M., Abend, A., Panchal, P., Kassam, Z., & Budree, S. (2018). 88-Does the Donor Matter? Microbiome Sequencing to Evaluate Lower Donor Efficacy in Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection. Gastroenterology, 154(6), S-25.
2018
Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality Opens a new window
Barnes, D., Ng, K., Smits, S., Sonnenburg, J., Kassam, Z., & Park, K. T. (2018). Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality. Journal of pediatric gastroenterology and nutrition.
2019
Donor Screening for Fecal Microbiota Transplantation Opens a new window
Kassam Z, et al. (2019). Donor Screening for Fecal Microbiota Transplantation. NEJM. doi: 10.1056/NEJMc1913670.
2020
Re-Evaluating the Evidence for Faecal Microbiota Transplantation ‘Super-Donors’ in Inflammatory Bowel Disease Opens a new window
Olesen, S., & Gerardin, Y. (2020). Re-Evaluating the Evidence for Faecal Microbiota Transplantation ‘Super-Donors’ in Inflammatory Bowel Disease. Journal Of Crohn's And Colitis, 15(3), 453-461. doi: 10.1093/ecco-jcc/jjaa170
2020
Challenges of Screening Prospective Stool Donors for Fecal Microbiota Transplantation Opens a new window
Dubois, N., Read, C., O’Brien, K., and Ling, K. (2020). Biological Research For Nursing. Challenges of Screening Prospective Stool Donors for Fecal Microbiota Transplantation. Retrieved from https://journals.sagepub.com/doi/abs/10.1177/1099800420941185
2014
OpenBiome remains open to serve the medical community Opens a new window
Smith, M., Kassam, Z., Edelstein, C., Burgess, J., Alm, E., & Ratner, M. et al. (2014). OpenBiome remains open to serve the medical community. Nature Biotechnology.
2014
Policy: How to regulate faecal transplants Opens a new window
Smith, M., Kelly, C., & Alm, E. (2014). Policy: How to regulate faecal transplants. Nature, 506(7488), 290-291. doi:10.1038/506290a
2015
Ensuring the safe and effective FDA regulation of fecal microbiota transplantation Opens a new window
Sachs, R., & Edelstein, C. (2015). Ensuring the safe and effective FDA regulation of fecal microbiota transplantation. Journal of Law and the Biosciences. 2. 10.1093/jlb/lsv032.
2015
Prospective Assessment of Donor Eligibility for Fecal Microbiota Transplantation at a Public Stool Bank: Results From the Evaluation of 1,387 Candidate Donors Opens a new window
Dubois, N., Ling, K., Osman, M., Burns, L., Mendolia, G., Blackler, D., Burgess, J., Edelstein, C., Noh, A., Vo, E., Alm E., Smith, M., and Kassam, Z. (2015). Prospective Assessment of Donor Eligibility for Fecal Microbiota Transplantation at a Public Stool Bank: Results From the Evaluation of 1,387 Candidate Donors. Idsa. Retrieved from https://idsa.confex.com/idsa/2015/webprogram/Paper52979.html
2015
Seeking safe stool: Canada needs a universal donor model Opens a new window
Edelstein, C., Daw, J., & Kassam, Z. (2015). Seeking safe stool: Canada needs a universal donor model. Canadian Medical Association Journal, 188(17-18), E431-E432. doi:10.1503/cmaj.150672
2016
Safety and Efficacy of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection From An International Public Stool Bank: Results From a 2050-Patient Multicenter Cohort Opens a new window
Osman, M., O'Brien, K., Stoltzner, Z., Ling, K., Koelsch, E., & Dubois, N. et al. (2016). Safety and Efficacy of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection From An International Public Stool Bank: Results From a 2050-Patient Multicenter Cohort. Open Forum Infectious Diseases, 3(suppl_1). doi:10.1093/ofid/ofw172.1668
2016
Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease Opens a new window
Fischer, M., Kao, D., Kelly, C., Kuchipudi, A., Jafri, S. M., Blumenkehl, M., ... & Cook, G. (2016). Fecal microbiota transplantation is safe and efficacious for recurrent or refractory Clostridium difficile infection in patients with inflammatory bowel disease. Inflammatory bowel diseases, 22(10), 2402-2409.
2017
Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals Opens a new window
Vujkovic-Cvijin, I., Rutishauser, R. L., Pao, M., Hunt, P. W., Lynch, S. V., McCune, J. M., & Somsouk, M. (2017). Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals. Gut microbes, 8(5), 440-450.
2017
Faecal microbiota transplantation for Clostridium difficile infection: a multicentre study of non-responders Opens a new window
Razik, R., Osman, M., Lieberman, A., Allegretti, J. R., & Kassam, Z. (2017). Faecal microbiota transplantation for Clostridium difficile infection: a multicentre study of non-responders. N Engl J Med, 368, 407-415.
2017
The Risk of Inflammatory Bowel Disease Flares after Fecal Microbiota Transplantation: Systematic Review and Meta-Analysis Opens a new window
Qazi, T., Amaratunga, T., Barnes, E. L., Fischer, M., Kassam, Z., & Allegretti, J. R. (2017). The risk of inflammatory bowel disease flares after fecal microbiota transplantation: Systematic review and meta-analysis. Gut microbes, 8(6), 574-588
2017
Fecal microbiota transplantation differentially influences the gut microbiota of Clostridium difficile infection and ileal pouch anal anastomosis patients Opens a new window
Piceno, Y. M., El-Nachef, N., Kassam, Z., Smith, M., Lynch, K., Zydek, M., ... & Lynch, S. (2017). Fecal Microbiota Transplantation Differentially Influences the Gut Microbiota of Clostridium Difficile Infection and Ileal Pouch Anal Anastomosis Patients. Gastroenterology, 152(5), S1006.
2017
Pediatric access to fecal microbiota transplantation for recurrent Clostridium difficile Infection in the United States and the impact of stool banks: a geospatial analysis Opens a new window
Panchal, P., Budree, S., Tu, E., Kahn, S. A., Allegretti, J. R., Fischer, M., ... & Osman, M. (2017). Pediatric Access to Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection in the United States and the Impact of Stool Banks: A Geospatial Analysis. Gastroenterology, 152(5), S849-S850.
2017
Systematic Review and Meta-Analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis Opens a new window
Narula, N., Kassam, Z., Yuan, Y., Colombel, J. F., Ponsioen, C., Reinisch, W., & Moayyedi, P. (2017). Systematic review and meta-analysis: fecal microbiota transplantation for treatment of active ulcerative colitis. Inflammatory bowel diseases, 23(10), 1702-1709.
2017
Prevalence of early antibiotic use post-fecal microbiota transplantation and corresponding risk of FMT failure. Opens a new window
Allegretti, J. R., Kao, D. H., Sitko, J., Fischer, M., & Kassam, Z. (2017). Prevalence of Early Antibiotic Use Post-Fecal Microbiotatransplantation and Corresponding Risk of FMT Failure. Gastroenterology, 152(5), S342-S343.
2017
Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis Opens a new window
Jacob, V., Crawford, C., Cohen-Mekelburg, S., Viladomiu, M., Putzel, G. G., Schneider, Y., ... & Ajami, N. J. (2017). Single delivery of high-diversity fecal microbiota preparation by colonoscopy is safe and effective in increasing microbial diversity in active ulcerative colitis. Inflammatory bowel diseases, 23(6), 903-911.
2017
Fecal microbiota transplant in severe and severe complicated Clostridium difficile: a promising treatment approach Opens a new window
Fischer, M., Sipe, B., Cheng, Y. W., Phelps, E., Rogers, N., Sagi, S., ... & Kassam, Z. (2017). Fecal microbiota transplant in severe and severe-complicated Clostridium difficile: A promising treatment approach. Gut microbes, 8(3), 289-302.
2017
Fecal microbiota transplantation is safe and effective for the treatment of Clostridium difficile infection in solid organ transplant recipients Opens a new window
Fischer, M., Khan, M., Phelps, E. L., Safdar, N., Misch, E. A., Kaur, N., ... & Xu, H. (2017). Fecal Microbiota Transplantation is Safe and Effective for the Treatment of Clostridium Difficile Infection in Solid Organ Transplant Recipients. Gastroenterology, 152(5), S1005.
2017
Stool Donor Body Mass Index Does Not Affect Recipient Weight After a Single Fecal Microbiota Transplantation for Clostridium difficile Infection Opens a new window
Fischer, M., Kao, D., Kassam, Z., Smith, J., Louie, T., Sipe, B., ... & Allegretti, J. R. (2017). Stool Donor Body Mass Index Does Not Affect Recipient Weight After a Single Fecal Microbiota Transplantation for C. difficile Infection. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association.
2017
Should we recommend anti-Clostridium difficile antibiotic or probiotic prophylaxis? Risk of Clostridium difficile infection with systemic antimicrobial therapy following successful fecal microbiota transplant Opens a new window
Fischer, M., Kao, D. H., Phelps, E. L., Smith, J. D., Roach, B., Kassam, Z., ... & Allegretti, J. R. (2017). Should we Recommend Anti-Clostridium Difficile Antibiotic or Probiotic Prophylaxis?: Risk of Clostridium Difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant. Gastroenterology, 152(5), S1005.
2017
Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease Opens a new window
Fischer, M., Bittar, M., Papa, E., Kassam, Z., & Smith, M. (2017). Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease. Gut microbes, 8(3), 205-207.
2017
Fecal microbiota transplantation is safe and effective in chronic pouchitis patients Opens a new window
El-Nachef, N., Piceno, Y. M., Kassam, Z., Zydek, M., Ablaza, A. J., Leith, T., ... & Lynch, S. (2017). Fecal Microbiota Transplantation is Safe and Effective in Chronic Pouchitis Patients. Gastroenterology, 152(5), S1009.
2017
The role of fecal microbiota transplantation in ulcerative colitis and Crohn’s disease: results from a parallel inflammatory bowel disease cohort study Opens a new window
El-Nachef, N., Piceno, Y. M., Kassam, Z., Ablaza, A. J., Zydek, M., Lynch, K., ... & Lynch, S. (2017). The Role of Fecal Microbiota Transplantation in Ulcerative Colitis and Crohn's Disease: Results from a Parallel Inflammatory Bowel Disease Cohort Study. Gastroenterology, 152(5), S1008.
2017
Profiling Living Bacteria Informs Preparation of Fecal Microbiota Transplantations Opens a new window
Chu, N. D., Smith, M. B., Perrotta, A. R., Kassam, Z., & Alm, E. J. (2017). Profiling living bacteria informs preparation of fecal microbiota transplantations. PloS one, 12(1), e0170922.
2017
Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors Opens a new window
Budree, S., Wong, W. F., Tu, E., Rao, S., Allegretti, J. R., Fischer, M., ... & Kassam, Z. (2017). Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors. Gastroenterology, 152(5), S349.
2017
The association of stool donor diet on microbial profile and clinical outcomes of fecal microbiota transplantation in clostridium difficile infection Opens a new window
Budree, S., Tu, E., Leith, T., Allegretti, J. R., Rao, S., Day, R., ... & Osman, M. (2017). The Association of Stool Donor Diet on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630-S631.
2017
The association of donor stool consistency by Bristol stool scale on microbial profile and clinical outcomes of fecal microbiota transplantation in Clostridium difficile infection Opens a new window
Budree, S., Rao, S., Allegretti, J. R., Fischer, M., Kelly, C. R., Smith, M., ... & Kassam, Z. (2017). The Association of Donor Stool Consistency by Bristol Stool Scale on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630.
2017
Donor stool processing time: the effect on the intestinal microbiome and clinical outcomes of fecal microbiota transplantation in Clostridium difficile Infection Opens a new window
Budree, S., Elliott, R. J., Rao, S., Njenga, M., Ladha, A., Allegretti, J. R., ... & Kassam, Z. (2017). Donor Stool Processing Time: The Effect on the Intestinal Microbiome and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S1006.
2017
Fecal microbiota transplant using a precision medicine approach is safe, associated with lower hospitalization risk and improved cognitive function in recurrent hepatic encephalopathy Opens a new window
Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E., Liu, E. J., Kheradman, R., ... & Alm, E. (2017). Fecal microbiota transplant using a precision medicine approach is safe, Associated with lower hospitalization risk and improved cognitive function in recurrent hepatic encephalopathy. Gastroenterology, 152(5), S906.
2017
Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial Opens a new window
Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., ... & Williams, R. (2017). Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Hepatology.
2017
Classifying Fecal Microbiota Transplantation Failure: An Observational Study Examining Timing and Characteristics of Fecal Microbiota Transplantation Failures. Opens a new window
Allegretti, J. R., Phelps, E., Allegretti, A., Xu, H., Fischer, M., & Kassam, Z. (2017). Classifying Fecal Microbiota Transplantation Failure: An Observational Study Examining Timing and Characteristics of Fecal Microbiota Transplantation Failures. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association.
2017
Early Antibiotic Use After Fecal Microbiota Transplantation Increases Risk of Treatment Failure Opens a new window
Allegretti, J. R., Kao, D., Sitko, J., Fischer, M., & Kassam, Z. (2017). Early Antibiotic Use After Fecal Microbiota Transplantation Increases Risk of Treatment Failure. Clinical Infectious Diseases, 66(1), 134-135.
2017
The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present and Future Opens a new window
Allegretti, J., Eysenbach, L. M., El-Nachef, N., Fischer, M., Kelly, C., & Kassam, Z. (2017). The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present, and Future. Inflammatory bowel diseases, 23(10), 1710-1717.
2018
Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation Opens a new window
Smillie, C. S., Sauk, J., Gevers, D., Friedman, J., Sung, J., Youngster, I., ... & Allegretti, J. R. (2018). Strain tracking reveals the determinants of bacterial engraftment in the human gut following fecal microbiota transplantation. Cell host & microbe, 23(2), 229-240.
2018
Scaling Pediatric Access to Fecal Microbiota Transplantation in the United States: A Time-Series Geospatial Analysis Opens a new window
Panchal, P., Kahn, S., Zellmer, C., Kassam, Z., Osman, M., Allegretti, J., ... & NASPGHAN FMT Special Interest Group. (2018, November). 533. Scaling Pediatric Access to Fecal Microbiota Transplantation in the United States: A Time-Series Geospatial Analysis. Open Forum Infectious Diseases (Vol. 5, No. suppl_1, pp. S197-S197). US: Oxford University Press.
2018
Scaling Access to Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in the United States: A Geospatial Time-Series Analysis from 2013 to 2017 Opens a new window
Panchal, P., Elliott, R. J., Budree, S., Osman, M., Allegretti, J. R., Kelly, C. R., ... & Kassam, Z. (2018). 1010-Scaling Access to Fecal Microbiota Transplantation for Recurrent Clostridium Difficle Infection in the United States: A Geospatial Time-Series Analysis from 2013 to 2017. Gastroenterology, 154(6), S-190.
2018
Scaling Safe Access to Fecal Microbiota Transplantation: Past, Present, and Future Opens a new window
Panchal, P., Budree, S., Scheeler, A., Medina, G., Seng, M., Wong, W. F., & Eliot, R. (2018). Scaling Safe Access to Fecal Microbiota Transplantation: Past, Present, and Future. Current Gastroenterology Reports, 20(4), 14.
2018
Early Results of Fecal Microbial Transplantation Protocol Implementation at a Community-based University Hospital Opens a new window
Duarte-Chavez, R., Wojda, T. R., Zanders, T. B., Geme, B., Fioravanti, G., & Stawicki, S. P. (2018). Early results of fecal microbial transplantation protocol implementation at a community-based university hospital. Journal of global infectious diseases, 10(2), 47.
2018
Do Clinical Factors Affect Microbial Engraftment After Fecal Microbiota Transplantation in Recurrent Clostridium difficile Infection? Opens a new window
Budree, S., Osman, M., Panchal, P., Shu, E., Carrellas, M., Kassam, Z., & Allegretti, J. (2018, November). 618. Do Clinical Factors Affect Microbial Engraftment After Fecal Microbiota Transplantation in Recurrent Clostridium difficile Infection?. Open Forum Infectious Diseases (Vol. 5, No. suppl_1, pp. S225-S226). US: Oxford University Press.
2018
Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection Opens a new window
Brown, J. R. M., Flemer, B., Joyce, S. A., Zulquernain, A., Sheehan, D., Shanahan, F., & O’Toole, P. W. (2018). Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection. BMC Gastroenterology, 18(1), 131.
2018
Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality. Opens a new window
Barnes, D., Ng, K., Smits, S., Sonnenburg, J., Kassam, Z., & Park, K. T. (2018). Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality. Journal of pediatric gastroenterology and nutrition.
2018
The 5D framework: a clinical primer for fecal microbiota transplantation to treat Clostridium difficile infection Opens a new window
Allegretti, J. R., Kassam, Z., Osman, M., Budree, S., Fischer, M., & Kelly, C. R. (2018). The 5D framework: a clinical primer for fecal microbiota transplantation to treat Clostridium difficile infection. Gastrointestinal endoscopy, 87(1), 18-29.
2018
Small Intestinal Bacterial Overgrowth: Should Screening Be Included in the Pre-fecal Microbiota Transplantation Evaluation? Opens a new window
Allegretti, J. R., Kassam, Z., & Chan, W. W. (2018). Small Intestinal Bacterial Overgrowth: Should Screening Be Included in the Pre-fecal Microbiota Transplantation Evaluation?. Digestive diseases and sciences, 63(1), 193-197.
2019
Outcomes of a Multidisciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis Opens a new window
Shin, J., Chaplin, A., Hays, R., Kolling, G., Vance, S., & Guerrant, R. et al. (2019). Outcomes of a Multidisciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis. Journal Of Clinical Medicine, 8(7), 1036. doi:10.3390/jcm8071036
2019
Where Stool is a Drug: International Approaches to Regulating the use of Fecal Microbiota for Transplantation Opens a new window
Scheeler A. Where Stool is a Drug: International Approaches to Regulating the use of Fecal Microbiota for Transplantation. J Law Med Ethics. 2019 Dec;47(4):524-540. doi: 10.1177/1073110519897729. PMID: 31957572.
2019
Nuts and Bolts of Fecal Microbiota Transplantation Opens a new window
Krajicek, E., Fischer, M., Allegretti, J., & Kelly, C. (2019). Nuts and Bolts of Fecal Microbiota Transplantation. Clinical Gastroenterology And Hepatology, 17(2), 345-352. doi:10.1016/j.cgh.2018.09.029
2019
Risk Factors for Gastrointestinal Symptoms Following Successful Eradication of Clostridium difficile by Fecal Microbiota Transplantation (FMT) Opens a new window
Allegretti, J.R., Kassam, Z., Fischer, M., Kelly, C., & Chan W.W. (2019). Risk Factors for Gastrointestinal Symptoms Following Successful Eradication of Clostridium difficile by Fecal Microbiota Transplantation (FMT). Journal Of Clinical Gastroenterology, 1. doi:10.1097/mcg.0000000000001194
2019
Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis? Opens a new window
Allegretti, J., Kao, D., Phelps, E., Roach, B., Smith, J., & Ganapini, V. et al. (2019). Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis?. Digestive Diseases And Sciences. doi:10.1007/s10620-018-5450-4
2019
The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications Opens a new window
Allegretti, J., Mullish, B., Kelly, C., & Fischer, M. (2019). The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications. The Lancet, 394(10196), 420-431. doi:10.1016/s0140-6736(19)31266-8
2019
Donor Screening for Fecal Microbiota Transplantation Opens a new window
Kassam Z, et al. (2019). Donor Screening for Fecal Microbiota Transplantation. NEJM. doi: 10.1056/NEJMc1913670.
2020
Shiga toxin-producing E. coli transmission via fecal microbiota transplant Opens a new window
Zellmer, C., Sater, M., Huntley, M., Osman, M., Olesen, S., & Ramakrishna, B. (2020). Shiga toxin-producing E. coli transmission via fecal microbiota transplant. Clinical Infectious Diseases. doi: 10.1093/cid/ciaa1486
2020
Power calculations for detecting differences in efficacy of fecal microbiota donors Opens a new window
Olesen SW. Power calculations for detecting differences in efficacy of fecal microbiota donors. Contemp Clin Trials Commun. 2020 Nov 6;20:100674. doi: 10.1016/j.conctc.2020.100674. PMID: 33241161; PMCID: PMC7672275.
2020
Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection Opens a new window
Allegretti, J., Mehta, S., Kassam, Z., Kelly, C., Kao, D., Xu, H., & Fischer, M. (2020). Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection. Digestive Diseases And Sciences. doi:10.1007/s10620-020-06198-2
2020
Ulcerative Proctitis in a Patient With a History of Fecal Microbiota Transplant for Clostridioides difficile Infection Opens a new window
Massaro, M., Vansia, J., & McGill, S. (2020). Ulcerative Proctitis in a Patient With a History of Fecal Microbiota Transplant for Clostridioides difficile Infection. ACG Case Reports Journal, 7(4), e00364. doi: 10.14309/crj.0000000000000364
2020
Systematic review: the global incidence of faecal microbiota transplantation-related adverse events from 2000 to 2020 Opens a new window
Marcella C, Cui B, Kelly CR, Ianiro G, Cammarota G, Zhang F. Systematic review: the global incidence of faecal microbiota transplantation-related adverse events from 2000 to 2020. Aliment Pharmacol Ther. 2020 Nov 7. doi: 10.1111/apt.16148. Epub ahead of print. PMID: 33159374.
2020
Fecal Microbiota Transplants Annually and Their Positive Clinical Impact Opens a new window
Mamoon, Lamia and Olesen, Scott W. Fecal Microbiota Transplants Annually and Their Positive Clinical Impact, Clinical and Translational Gastroenterology: November 2020 - Volume 11 - Issue 11 - p e00247 doi: 10.14309/ctg.0000000000000247
2020
Monitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment Opens a new window
Kelly, C., Laine, L., & Wu, G. (2020). Monitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment. Gastroenterology, 159(6), 2004-2006. doi: 10.1053/j.gastro.2020.08.039
2020
Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel Opens a new window
Ianiro, G., Mullish, B., Kelly, C., Sokol, H., Kassam, Z., & Ng, S. et al. (2020). Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel. The Lancet Gastroenterology & Hepatology. doi:10.1016/s2468-1253(20)30082-0
2020
Long-Term Outcomes Following Multiply Recurrent Clostridioides Difficile Infection and Fecal Microbiota Transplantation Opens a new window
Dawwas G, Brensinger CM, Vajravelu RK, Wu Q, Kelly CR, Laine L, Wu GD, Lewis JD. Long-Term Outcomes Following Multiply Recurrent Clostridioides Difficile Infection and Fecal Microbiota Transplantation. Clin Gastroenterol Hepatol. 2020 Dec 8:S1542-3565(20)31642-6. doi: 10.1016/j.cgh.2020.12.004. Epub ahead of print. PMID: 33307184
2020
Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation Opens a new window
Jessica R. Allegretti, Ryan J. Elliott, Alim Ladha, Mary Njenga, Kurt Warren, Kelsey O’Brien, Shrish Budree, Majdi Osman, Monika Fischer, Colleen R. Kelly & Zain Kassam (2020): Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation. Gut Microbes, DOI: 10.1080/19490976.2020.1768777
2021
Fecal Microbiota Transplantation: The Evolving Risk Landscape Opens a new window
Gupta S, Mullish BH, Allegretti JR. Fecal Microbiota Transplantation: The Evolving Risk Landscape. Am J Gastroenterol. 2021 Feb 5. doi: 10.14309/ajg.0000000000001075. Epub ahead of print. PMID: 33606488.
2021
Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children Opens a new window
Nicholson MR, Mitchell PD, Alexander E, Ballal S, Bartlett M, Becker P, Davidovics Z, Docktor M, Dole M, Felix G, Gisser J, Hourigan SK, Jensen MK, Kaplan JL, Kelsen J, Kennedy M, Khanna S, Knackstedt E, Leier M, Lewis J, Lodarek A, Michail S, Oliva-Hemker M, Patton T, Queliza K, Russell GH, Singh N, Solomon A, Suskind DL, Werlin S, Kellermayer R, Kahn SA. Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children. Clin Gastroenterol Hepatol. 2020 Mar;18(3):612-619.e1. doi: 10.1016/j.cgh.2019.04.037. Epub 2019 Apr 19. PMID: 31009795; PMCID: PMC7549313.
2021
Current Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children Opens a new window
Nicholson, M., Hourigan, S., Conrad, M., Goyal, A., Jensen, K., & Kelsen, J. et al. (2021). Current Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children. American Journal Of Gastroenterology, Publish Ahead of Print. doi: 10.14309/ajg.0000000000001350
2021
Fecal Microbiota Transplantation Is Safe for Clostridiodies difficile Infection in Patients with Solid Tumors Opens a new window
Mendelsohn, R., Kaltsas, A., King, S., Hwang, C., Kassam, Z., & Abend, A. et al. (2021). Fecal Microbiota Transplantation Is Safe for Clostridiodies difficile Infection in Patients with Solid Tumors Undergoing Chemotherapy. Digestive Diseases And Sciences. doi: 10.1007/s10620-021-07024-z
2021
Fecal Microbiota Transplantation for Recurrent C difficile Infection During the COVID-19 Pandemic Opens a new window
Khanna, S., Tande, A., Rubin, D., Khoruts, A., Kahn, S., & Pardi, D. (2021). Fecal Microbiota Transplantation for Recurrent C difficile Infection During the COVID-19 Pandemic. Mayo Clinic Proceedings, 96(6), 1418-1425. doi: 10.1016/j.mayocp.2021.04.005
2021
Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry Opens a new window
Kelly, C., Yen, E., Grinspan, A., Kahn, S., Atreja, A., & Lewis, J. et al. (2021). Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology, 160(1), 183-192.e3. doi: 10.1053/j.gastro.2020.09.038
2021
Updates and Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children Opens a new window
Hourigan, S., Nicholson, M., Kahn, S., & Kellermayer, R. (2021). Updates and Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children. Journal Of Pediatric Gastroenterology & Nutrition, Publish Ahead of Print. doi: 10.1097/mpg.0000000000003229
2021
Oral Fecal Microbiota Transplant Capsules Are Safe and Effective for Recurrent Clostridioides difficile Infection Opens a new window
Du, C., Luo, Y., Walsh, S., & Grinspan, A. (2021). Oral Fecal Microbiota Transplant Capsules Are Safe and Effective for Recurrent Clostridioides difficile Infection. Journal Of Clinical Gastroenterology, 55(4), 300-308. doi: 10.1097/mcg.0000000000001495
2021
Stool Banking for Fecal Microbiota Transplantation: Methods and Operations at a Large Stool Bank Opens a new window
Chen, J., Zaman, A., Ramakrishna, B., & Olesen, S. (2021). Stool Banking for Fecal Microbiota Transplantation: Methods and Operations at a Large Stool Bank. Frontiers In Cellular And Infection Microbiology, 11. doi: 10.3389/fcimb.2021.622949
2022
Pilot study of autologous fecal microbiota transplants in nursing home residents: Feasibility and safety Opens a new window
Liu CK, Seo J, Pravodelov V, Frazier S, Guy M, Concilio K, Lau-Ng R, Brandeis G, Watson J, van der Velde J, Olesen SW, Budree S, Njenga M, Kassam Z, Osman M. Pilot study of autologous fecal microbiota transplants in nursing home residents: Feasibility and safety. Contemp Clin Trials Commun. 2022 Mar 7;27:100906. doi: 10.1016/j.conctc.2022.100906. PMID: 35299780; PMCID: PMC8921299
2014
Review of the Emerging Treatment of Clostridium difficile Infection with Fecal Microbiota Transplantation and Insights into Future Challenges Opens a new window
Kassam, Z., Lee, C., & Hunt, R. (2014). Review of the Emerging Treatment of Clostridium difficile Infection with Fecal Microbiota Transplantation and Insights into Future Challenges. Clinics In Laboratory Medicine, 34(4), 787-798. doi:10.1016/j.cll.2014.08.007
2016
Safety and Efficacy of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection From An International Public Stool Bank: Results From a 2050-Patient Multicenter Cohort Opens a new window
Osman, M., O'Brien, K., Stoltzner, Z., Ling, K., Koelsch, E., & Dubois, N. et al. (2016). Safety and Efficacy of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection From An International Public Stool Bank: Results From a 2050-Patient Multicenter Cohort. Open Forum Infectious Diseases, 3(suppl_1). doi:10.1093/ofid/ofw172.1668
2016
Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease Opens a new window
Fischer, M., Kao, D., Kelly, C., Kuchipudi, A., Jafri, S. M., Blumenkehl, M., ... & Cook, G. (2016). Fecal microbiota transplantation is safe and efficacious for recurrent or refractory Clostridium difficile infection in patients with inflammatory bowel disease. Inflammatory bowel diseases, 22(10), 2402-2409.
2017
Faecal microbiota transplantation for Clostridium difficile infection: a multicentre study of non-responders Opens a new window
Razik, R., Osman, M., Lieberman, A., Allegretti, J. R., & Kassam, Z. (2017). Faecal microbiota transplantation for Clostridium difficile infection: a multicentre study of non-responders. Med J Aust; 207 (4): 159-160.
2017
Pediatric access to fecal microbiota transplantation for recurrent Clostridium difficile Infection in the United States and the impact of stool banks: a geospatial analysis Opens a new window
Panchal, P., Budree, S., Tu, E., Kahn, S. A., Allegretti, J. R., Fischer, M., ... & Osman, M. (2017). Pediatric Access to Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection in the United States and the Impact of Stool Banks: A Geospatial Analysis. Gastroenterology, 152(5), S849-S850.
2017
Fecal microbiota transplantation is safe and effective for the treatment of Clostridium difficile infection in solid organ transplant recipients Opens a new window
Piceno, Y. M., El-Nachef, N., Kassam, Z., Smith, M., Lynch, K., Zydek, M., ... & Lynch, S. (2017). Fecal Microbiota Transplantation Differentially Influences the Gut Microbiota of Clostridium Difficile Infection and Ileal Pouch Anal Anastomosis Patients. Gastroenterology, 152(5), S1006.
2017
Fecal microbiota transplantation differentially influences the gut microbiota of Clostridium difficile infection and ileal pouch anal anastomosis patients Opens a new window
Piceno, Y. M., El-Nachef, N., Kassam, Z., Smith, M., Lynch, K., Zydek, M., ... & Lynch, S. (2017). Fecal Microbiota Transplantation Differentially Influences the Gut Microbiota of Clostridium Difficile Infection and Ileal Pouch Anal Anastomosis Patients. Gastroenterology, 152(5), S1006.
2017
A Surgical Clostridium-associated Risk of Death Score Predicts Mortality after Colectomy for Clostridium difficile Opens a new window
Kulaylat, A. S., Kassam, Z., Hollenbeak, C. S., & Stewart Sr, D. B. (2017). A Surgical Clostridium-Associated Risk of Death Score Predicts Mortality After Colectomy for Clostridium difficile. Diseases of the Colon & Rectum, 60(12), 1285-1290.
2017
Should we recommend anti-Clostridium difficile antibiotic or probiotic prophylaxis? Risk of Clostridium difficile infection with systemic antimicrobial therapy following successful fecal microbiota transplant Opens a new window
Fischer, M., Kao, D. H., Phelps, E. L., Smith, J. D., Roach, B., Kassam, Z., ... & Allegretti, J. R. (2017). Should we Recommend Anti-Clostridium Difficile Antibiotic or Probiotic Prophylaxis?: Risk of Clostridium Difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant. Gastroenterology, 152(5), S1005.
2017
Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease Opens a new window
Fischer, M., Bittar, M., Papa, E., Kassam, Z., & Smith, M. (2017). Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease. Gut microbes, 8(3), 205-207.
2017
Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors Opens a new window
Budree, S., Wong, W. F., Tu, E., Rao, S., Allegretti, J. R., Fischer, M., ... & Kassam, Z. (2017). Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors. Gastroenterology, 152(5), S349.
2017
The association of stool donor diet on microbial profile and clinical outcomes of fecal microbiota transplantation in clostridium difficile infection Opens a new window
Budree, S., Tu, E., Leith, T., Allegretti, J. R., Rao, S., Day, R., ... & Osman, M. (2017). The Association of Stool Donor Diet on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630-S631.
2017
The association of donor stool consistency by Bristol stool scale on microbial profile and clinical outcomes of fecal microbiota transplantation in Clostridium difficile infection Opens a new window
Budree, S., Rao, S., Allegretti, J. R., Fischer, M., Kelly, C. R., Smith, M., ... & Kassam, Z. (2017). The Association of Donor Stool Consistency by Bristol Stool Scale on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630.
2017
Donor stool processing time: the effect on the intestinal microbiome and clinical outcomes of fecal microbiota transplantation in Clostridium difficile Infection Opens a new window
Budree, S., Elliott, R. J., Rao, S., Njenga, M., Ladha, A., Allegretti, J. R., ... & Kassam, Z. (2017). Donor Stool Processing Time: The Effect on the Intestinal Microbiome and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S1006.
2017
Asymptomatic Clostridium difficile carriage rate post-fecal microbiota transplant is low: a prospective clinical and stool assessment. Opens a new window
Allegretti, J. R., Allegretti, A. S., Phelps, E., Xu, H., Kassam, Z., & Fischer, M. (2017). Asymptomatic Clostridium difficile carriage rate post-fecal microbiota transplant is low: a prospective clinical and stool assessment. Clinical Microbiology and Infection
2018
Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience Opens a new window
Cheng, Y. W., Phelps E., Ganapini V., Khan N., Ouyang, F., Xu H., … & Fischer M. (2018) Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience. American Journal of Transplantation, 10.1111/ajt.15058.
2018
Do Clinical Factors Affect Microbial Engraftment After Fecal Microbiota Transplantation in Recurrent Clostridium difficile Infection? Opens a new window
Budree, S., Osman, M., Panchal, P., Shu, E., Carrellas, M., Kassam, Z., & Allegretti, J. (2018, November). 618. Do Clinical Factors Affect Microbial Engraftment After Fecal Microbiota Transplantation in Recurrent Clostridium difficile Infection?. Open Forum Infectious Diseases (Vol. 5, No. suppl_1, pp. S225-S226). US: Oxford University Press.
2018
Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection Opens a new window
Brown, J. R. M., Flemer, B., Joyce, S. A., Zulquernain, A., Sheehan, D., Shanahan, F., & O’Toole, P. W. (2018). Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection. BMC Gastroenterology, 18(1), 131.
2018
Frail Heart, Friable Colon: A Case Report of Fecal Microbiota Transplant for Refractory Clostridium difficile Infection in a Patient with Recent Trans-Catheter Aortic Valve Replacement Opens a new window
Bhanvadia, A. (2018) Frail Heart, Friable Colon: A Case Report of Fecal Microbiota Transplant for Refractory Clostridium difficile Infection in a Patient with Recent Trans-Catheter Aortic Valve Replacement. J Inflam Bowel Dis & Discord 3(1): 124.
2018
The 5D framework: a clinical primer for fecal microbiota transplantation to treat Clostridium difficile infection Opens a new window
Allegretti, J. R., Kassam, Z., Osman, M., Budree, S., Fischer, M., & Kelly, C. R. (2018). The 5D framework: a clinical primer for fecal microbiota transplantation to treat Clostridium difficile infection. Gastrointestinal endoscopy, 87(1), 18-29.
2018
Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose Opens a new window
Allegretti, J. R., Fischer, M., Sashidar V. S., Bohm, M. E., Fadda, H. M., Ranmal, S. R., Budree, S., Basit, A. W., Glettif, D. L., de la Serna, E. L., Gentile, A., Gerardin, Y., Timberlake, S. T., Sadovsky, R., Smith, M., Kassam, Z. (2018). Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose. Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-018-5396-6.
2019
Faecal microbiota transplant decreases mortality in severe and fulminant Clostridioides difficile infection in critically ill patients Opens a new window
Tixier, E., Verheyen, E., Ungaro, R., & Grinspan, A. (2019). Faecal microbiota transplant decreases mortality in severe and fulminant Clostridioides difficile infection in critically ill patients. Alimentary Pharmacology & Therapeutics. doi:10.1111/apt.15526
2019
Outcomes of a Multidisciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis Opens a new window
Shin, J., Chaplin, A., Hays, R., Kolling, G., Vance, S., & Guerrant, R. et al. (2019). Outcomes of a Multidisciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis. Journal Of Clinical Medicine, 8(7), 1036. doi:10.3390/jcm8071036
2019
Patients Eligible for Trials of Microbe-based Therapeutics do not Represent the Population With Recurrent Clostridioides difficile Infection Opens a new window
Kelly, C., Fischer, M., Grinspan, A., & Allegretti, J. (2019). Patients Eligible for Trials of Microbe-based Therapeutics do not Represent the Population With Recurrent Clostridioides difficile Infection. Clinical Gastroenterology And Hepatology. doi:10.1016/j.cgh.2019.06.034
2019
Bezlotoxumab use as adjunctive therapy with the third fecal microbiota transplant in refractory recurrent Clostridium difficilecolitis; a case report and concise literature review Opens a new window
Kaako, A., Al-Amer, M., & Abdeen, Y. (2019). Bezlotoxumab use as adjunctive therapy with the third fecal microbiota transplant in refractory recurrent Clostridium difficile colitis; a case report and concise literature review. Anaerobe, 55, 112-116. doi:10.1016/j.anaerobe.2018.11.010
2019
Treatment of Severe and Fulminnant Clostridioides difficile Infection Opens a new window
Cheng, Y., & Fischer, M. (2019). Treatment of Severe and Fulminnant Clostridioides difficile Infection. Current Treatment Options In Gastroenterology. doi:10.1007/s11938-019-00262-1
2019
Clinical Predictors of Recurrence After Primary Clostridioides difficile Infection: A Prospective Cohort Study Opens a new window
Allegretti, J., Marcus, J., Storm, M., Sitko, J., Kennedy, K., Gerber, G., & Bry, L. (2019). Clinical Predictors of Recurrence After Primary Clostridioides difficile Infection: A Prospective Cohort Study. Digestive Diseases And Sciences. doi:10.1007/s10620-019-05900-3
2019
Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis? Opens a new window
Allegretti, J., Kao, D., Phelps, E., Roach, B., Smith, J., & Ganapini, V. et al. (2019). Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis?. Digestive Diseases And Sciences. doi:10.1007/s10620-018-5450-4
2019
Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Lose Dose Opens a new window
Allegretti, J., Fischer, M., Sagi, S., Bohm, M., Fadda, H., & Ranmal, S. et al. (2018). Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Lose Dose. Digestive Diseases And Sciences, 64(6), 1672-1678. doi:10.1007/s10620-018-5396-6
2020
Diagnosis and Treatment of Clostridioides (Clostridium) difficile Infection in Adults in 2020 Opens a new window
Rao, K., & Malani, P. (2020). Diagnosis and Treatment of Clostridioides (Clostridium) difficile Infection in Adults in 2020. JAMA, 323(14), 1403. doi: 10.1001/jama.2019.3849
2020
Long-Term Efficacy and Safety of Fecal Microbiota Transplantation for Treatment of Recurrent Clostridioides difficile Infection Opens a new window
Perler, B., Chen, B., Phelps, E., Allegretti, J., Fischer, M., & Ganapini, V. et al. (2020). Long-Term Efficacy and Safety of Fecal Microbiota Transplantation for Treatment of Recurrent Clostridioides difficile Infection. Journal Of Clinical Gastroenterology, 1. doi:10.1097/mcg.0000000000001281
2020
Fecal microbiota transplantation "donor effects" are not clinically relevant for Clostridioides difficile infection Opens a new window
Olesen SW. Fecal microbiota transplantation "donor effects" are not clinically relevant for Clostridioides difficile infection. Gastroenterology. 2020 Dec 30:S0016-5085(20)35620-1. doi: 10.1053/j.gastro.2020.12.057. Epub ahead of print. PMID: 33387515.
2020
Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites Opens a new window
Martinez-Gili, L., McDonald, J., Liu, Z., Kao, D., Allegretti, J., & Monaghan, T. et al. (2020). Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites. Gut Microbes, 12(1), 1810531. doi: 10.1080/19490976.2020.1810531
2020
Fecal Microbiota Transplants Annually and Their Positive Clinical Impact Opens a new window
Mamoon, Lamia and Olesen, Scott W. Fecal Microbiota Transplants Annually and Their Positive Clinical Impact, Clinical and Translational Gastroenterology: November 2020 - Volume 11 - Issue 11 - p e00247 doi: 10.14309/ctg.0000000000000247
2020
Fecal Microbiota Transplant Decreases Mortality in Patients with Refractory Severe or Fulminant Clostridioides difficile Infection Opens a new window
Cheng, Y., Phelps, E., Nemes, S., Rogers, N., Sagi, S., & Bohm, M. et al. (2020). Fecal Microbiota Transplant Decreases Mortality in Patients with Refractory Severe or Fulminant Clostridioides difficile Infection. Clinical Gastroenterology And Hepatology. doi:10.1016/j.cgh.2019.12.029
2020
Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection Opens a new window
Allegretti, J., Kelly, C., Grinspan, A., Mullish, B., Kassam, Z., & Fischer, M. (2020). Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection. Gastroenterology, 159(5), 1982-1984. doi: 10.1053/j.gastro.2020.07.045
2020
Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation Opens a new window
Jessica R. Allegretti, Ryan J. Elliott, Alim Ladha, Mary Njenga, Kurt Warren, Kelsey O’Brien, Shrish Budree, Majdi Osman, Monika Fischer, Colleen R. Kelly & Zain Kassam (2020): Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation. Gut Microbes, DOI: 10.1080/19490976.2020.1768777
2020
Treatment of Recurrent Clostridium difficile Infection in an Immunocompromised Patient with Severe Neutropenia Not Responding to Standard Therapy Opens a new window
AlQahtani, H., Baloch, S., & Tabb, D. (2020). Treatment of Recurrent Clostridium difficile Infection in an Immunocompromised Patient with Severe Neutropenia Not Responding to Standard Therapy. Case Reports In Infectious Diseases, 2020, 1-4. doi:10.1155/2020/3089023
2021
Systematic Review with Meta-Analysis: Fecal Microbiota Transplantation for Severe or Fulminant Clostridioides difficile Opens a new window
Tixier EN, Verheyen E, Luo Y, Grinspan LT, Du CH, Ungaro RC, Walsh S, Grinspan AM. Systematic Review with Meta-Analysis: Fecal Microbiota Transplantation for Severe or Fulminant Clostridioides difficile. Dig Dis Sci. 2021 Mar 22. doi: 10.1007/s10620-021-06908-4. Epub ahead of print. PMID: 33748913.
2021
Fecal Microbiota Transplantation for Severe or Fulminant Clostridioides difficile Infection Opens a new window
Song YN, Yang DY, Veldhuyzen van Zanten S, Wong K, McArthur E, Song CZ, Ianiro G, Cammarota G, Kelly C, Fischer M, Russell L, Kao D. Fecal Microbiota Transplantation for Severe or Fulminant Clostridioides difficile Infection: Systematic Review and Meta-analysis. J Can Assoc Gastroenterol. 2021 Jul 23;5(1):e1-e11. doi: 10.1093/jcag/gwab023. PMID: 35118227; PMCID: PMC8806043.
2021
Management of Severe and Severe/Complicated Clostridoides difficile Infection using Sequential Fecal Microbiota Transplant by Retention Enema Opens a new window
Rupawala AH, Gachette D, Bakhit M, Jimoh L, Kelly CR. Management of Severe and Severe/Complicated Clostridoides difficile Infection using Sequential Fecal Microbiota Transplant by Retention Enema. Clin Infect Dis. 2021 Jan 21:ciab041. doi: 10.1093/cid/ciab041. Epub ahead of print. PMID: 33476379.
2021
Pediatric Fecal Microbiota Transplantation in Recurrent Clostridioides Difficile Opens a new window
Parnell JM, Nicholson MR, Kellermayer R, Kahn SA. Pediatric Fecal Microbiota Transplantation in Recurrent Clostridioides Difficile. Pediatr Ann. 2021 Dec;50(12):e515-e521. doi: 10.3928/19382359-20211111-01. Epub 2021 Dec 1. PMID: 34889135.
2021
The contribution of bile acid metabolism to the pathogenesis of Clostridioides difficile infection Opens a new window
Mullish, B., & Allegretti, J. (2021). The contribution of bile acid metabolism to the pathogenesis of Clostridioides difficile infection. Therapeutic Advances In Gastroenterology, 14, 175628482110177. doi: 10.1177/17562848211017725
2021
Hospital-onset Clostridioides difficile infections during the COVID-19 pandemic Opens a new window
Luo Y, Grinspan LT, Fu Y, Adams-Sommer V, Willey DK, Patel G, Grinspan AM. Hospital-onset Clostridioides difficile infections during the COVID-19 pandemic. Infect Control Hosp Epidemiol. 2021 Sep;42(9):1165-1166. doi: 10.1017/ice.2020.1223. Epub 2020 Sep 23. PMID: 32962772; PMCID: PMC7545245.
2021
ACG Clinical Guidelines Opens a new window
Kelly, C., Fischer, M., Allegretti, J., LaPlante, K., Stewart, D., & Limketkai, B. et al. (2021). ACG Clinical Guidelines. American Journal Of Gastroenterology, Publish Ahead of Print. doi: 10.14309/ajg.0000000000001278
2021
Cost-effectiveness analysis of sequential fecal microbiota transplantation for fulminant Clostridioides difficile infection Opens a new window
Gupta S, Zhu J, McCarty TR, Pruce J, Kassam Z, Kelly C, Fischer M, Allegretti JR. Cost-effectiveness analysis of sequential fecal microbiota transplantation for fulminant Clostridioides difficile infection. J Gastroenterol Hepatol. 2021 Sep;36(9):2432-2440. doi: 10.1111/jgh.15483. Epub 2021 Mar 17. PMID: 33682170.
2021
FMT for Severe C. difficile Infection: If at First You Do No Harm, the Second Time’s a Charm Opens a new window
Grinspan, A. (2020). FMT for Severe C. difficile Infection: If at First You Do No Harm, the Second Time’s a Charm. Digestive Diseases And Sciences, 66(1), 5-6. doi: 10.1007/s10620-020-06309-z
2021
Heterogeneity of Randomized Controlled Trials of Fecal Microbiota Transplantation in Recurrent Clostridioides difficile Infection Opens a new window
Feuerstadt P, Aroniadis OC, Svedlund FL, Garcia M, Stong L, Boules M, Khanna S. Heterogeneity of Randomized Controlled Trials of Fecal Microbiota Transplantation in Recurrent Clostridioides difficile Infection. Dig Dis Sci. 2021 Jul 18. doi: 10.1007/s10620-021-07141-9. Epub ahead of print. PMID: 34275058.
2021
Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease: A Clinician's Dilemma Opens a new window
Conrad MA, Kelsen JR. Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease: A Clinician's Dilemma. J Pediatric Infect Dis Soc. 2021 Aug 3:piab069. doi: 10.1093/jpids/piab069. Epub ahead of print. PMID: 34343321.
2021
Prevalence and impact of Clostridioides difficile infection among hospitalized patients with coranavirus disease 2019 Opens a new window
Allegretti, J., Nije, C., McClure, E., Redd, W., Wong, D., & Zhou, J. et al. (2021). Prevalence and impact of Clostridioides difficile infection among hospitalized patients with coranavirus disease 201 9. JGH Open, 5(5), 622-625. doi: 10.1002/jgh3.12497
2021
Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection Opens a new window
Allegretti, J., Mehta, S., Kassam, Z., Kelly, C., Kao, D., Xu, H., & Fischer, M. (2020). Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection. Digestive Diseases And Sciences, 66(1), 213-217. doi: 10.1007/s10620-020-06198-2
2022
Effectiveness and Safety of Fecal Microbiota Transplantation for Clostridioides Difficile Infection: Results From a 5344-Patient Cohort Study Opens a new window
Osman M, Budree S, Kelly CR, Panchal P, Allegretti JR, Kassam Z; OPENBIOME COLLABORATORS. Effectiveness and Safety of Fecal Microbiota Transplantation for Clostridioides Difficile Infection: Results From a 5344-Patient Cohort Study. Gastroenterology. 2022 Apr 7:S0016-5085(22)00351-1. doi: 10.1053/j.gastro.2022.03.051. Epub ahead of print. PMID: 35398345.
July 2021
Efficacy of Fecal Microbiota Transplantation: Current Evidence on Clinical Cure for FMT for the Treatment of Recurrent C. difficile Infection
Controlled clinical trials and observational studies of Fecal Microbiota Transplantation (FMT) as a treatment for C. difficile infection (CDI) have reported cure rates ranging from 68%-100%. However, such trials and studies have varying definitions of recurrent C. difficile, use different FMT formulations and delivery methods, and treat different patient populations. This paper reviews important points to consider when extrapolating existing efficacy data to the unique situation of an individual patient.
July 2021
Evaluating a Patient for FMT (For the Treatment of C. difficile)
Fecal Microbiota Transplantation (FMT) has been shown to treat 80-90% of C. difficile infections not responsive to antibiotic therapy in clinical trials and real-world settings. However, the utility of FMT depends on accurate CDI diagnosis and patient selection. As many as 25% of patients may be incorrectly referred for FMT. This paper covers the considerations when evaluating patients for FMT for the treatment of C. difficile.
July 2021
Current Evidence on the Safety of Fecal Microbiota Transplantation (FMT) for C. difficile infection
In this paper, we provide an overview on the safety of FMT and important points to consider about the procedure. The perspectives presented here draw from the general safety of FMT sourced from universal stool banks (like OpenBiome) and hospital-based stool banks. This paper is aimed at physicians and healthcare professionals caring for patients being considered for FMT as well as patients themselves. The information reviewed here will help ensure that patients are fully informed of the safety profile of FMT and potential risks associated with the procedure before undergoing treatment.
July 2021
Tracking Patient Outcomes and Adverse Events: Considerations for Pharmacovigilance
Detection and response to reported safety events is one of a stool bank's most important roles. A robust material tracking and pharmacovigilance program enables timely responses to suspected adverse events including safety measures to mitigate risk to patients receiving FMT at centers being supplied by the stool bank. This paper presents OpenBiome's material tracking and pharmacovigilance program as an example for surveilling patient responses to FMT.
June 2021
When is an FMT Treatment Ready for Use? Health Monitoring and Material Release
Stool banking is a complex, multi-step process that includes screening and monitoring donor health as well as manufacturing fecal microbiota transplantation (FMT) preparations from donated stool. To help ensure that FMT preparations meet the stool bank’s quality and safety standards, a Quality Department reviews all information associated with an FMT preparation and its donor to verify that it is suitable for patient treatment. This paper outlines and discusses basic quality checks that FMT material should pass before it is released for clinical use.
July 2021
From Stool Donation to FMT Preparation: The Logistics of FMT Manufacturing
Fecal microbiota transplantation (FMT) preparations comprise minimally processed stool that retain a broad fraction of the stool donor’s complete microbiome. In clinical trials and real-world settings, FMT has been shown to treat approximately 80% of antibiotic-resistant C. difficile infections and is the standard of treatment for recurrent C. difficile. This paper, using OpenBiome as an example, reviews important considerations for manufacturing FMT preparations including safety and operational measures. Note: Considerations for donor screening are covered separately in a white paper titled “Clinical Considerations for Donor Selection”
July 2021
Clinical Considerations for Donor Screening
Evaluating the health of stool donors providing Fecal Microbiota Transplantation (FMT) material is a crucial and dynamic aspect of stool banking. Donor selection criteria may vary depending on multiple factors such as geography and patient population, and is continually being updated to reflect the latest understanding of FMT and the microbiome. This paper reviews clinical considerations underlying donor selection using OpenBiome’s screening criteria as an example.
July 2021
How to Recruit and Engage Stool Donors
Stool banking depends on a pool of committed and healthy stool donors. Building a sustainable donor pool can be difficult as less than 3% of prospective donors may pass health screenings, necessitating a large recruitment effort. This paper reviews several considerations for recruiting stool donors including guidance on advertising, designing incentives, and maintaining clear communication with prospective and active donors.
July 2021
Regulatory Oversight of Fecal Microbiota Transplantation (FMT): Consideration for Treating Clinicians
Fecal microbiota transplantation (FMT) follows a unique model of federal oversight in the United States. Although the U.S. Food and Drug Administration (FDA) considers FMT an investigational new drug, physicians may use FMT to treat patients with recurrent C. difficile infection under the agency’s policy of “enforcement discretion.” This document provides answers to frequently asked questions regarding the regulation of FMT, with an emphasis on the U.S. context.
July 2021
Fecal Microbiota Transplantation: An Introduction to FMT, its History, and Therapeutic Potential
Fecal Microbiota Transplantation (FMT) has a long history dating back to 300 AD China but has only recently been adopted by Western medical practice. In this paper, we review the basic definition of Fecal Microbiota Transplantation, its development into the standard for care for recurrent C. difficile, and how it may advance medical care for other illnesses.
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