Our Insights

We’ve built this living repository to share our expertise on the microbiome and fecal microbiota transplantation (FMT). This digital library contains white papers and academic publications describing the knowledge gleaned from treating more than 64,000 patients with FMT preparations and collaborating on more than 40 clinical trials across 30 disease indications.

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Academic Publication

2016

Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer external link icon Opens a new window

van Beurden, Y.H., van Gils, T., van Gils, N.A., Kassam, Z., Mulder, C.J., Aparicio-Pagés, N. (2016) Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer. J Gastrointestin Liver Dis., 25(3), 385-8.

Academic Publication

2018

Fecal Microbiota Transplantation Improves Gastrointestinal Graft-Versus-Host Disease and Restores the Microbiome: A Pediatric Experience external link icon Opens a new window

Wong, W. F., Budree, S., Osman, M., Panchal, P., Kassam, Z., Corkins, M. R., ... & Maron, G. M. (2018). Tu1882-Fecal Microbiota Transplantation Improves Gastrointestinal Graft-Versus-Host Disease and Restores the Microbiome: A Pediatric Experience. Gastroenterology, 154(6), S-1046.

Academic Publication

2018

Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort external link icon Opens a new window

Gurry, T., HST Microbiome Consortium*, Gibbons, S. M., Nguyen, L., Kearney, S. M., Ananthakrishnan, A., Jiang, X., Duvallet, C., Kassam, Z., … Alm, E. J. (2018). Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort. Scientific Reports, 8(1), 12699. doi:10.1038/s41598-018-30783-1

Academic Publication

2018

HIV-exposure, early life feeding practices and delivery mode impacts on faecal bacterial profiles in a South African birth cohort external link icon Opens a new window

Claassen-Weitz, S., Gardner-Lubbe, S., Nicol, P., Botha, G., Mounaud, S., Shankar, J., ... & Nicol, M. P. (2018). HIV-exposure, early life feeding practices and delivery mode impacts on faecal bacterial profiles in a South African birth cohort. Scientific Reports, 8(1), 5078.

Academic Publication

2018

Intestinal Microbial and Metabolic Alterations Following Successful Fecal Microbiota Transplant for D-Lactic Acidosis external link icon Opens a new window

Bulik-Sullivan, E. C., Roy, S., Elliott, R. J., Kassam, Z., Lichtman, S. N., Carroll, I. M., & Gulati, A. S. (2018). Intestinal microbial and metabolic alterations following successful fecal microbiota transplant for D-lactic acidosis. Journal of Pediatric Gastroenterology and Nutrition, 67(4), 483-487.

Academic Publication

2019

Microbiome predictors of dysbiosis and VRE decolonization in patients with recurrent C. difficile infections in a multi-center retrospective study external link icon Opens a new window

Santiago, M., Eysenbach, L., Allegretti, J., Aroniadis, O., J. Brandt, L., & Fischer, M. et al. (2019). Microbiome predictors of dysbiosis and VRE decolonization in patients with recurrent C. difficile infections in a multi-center retrospective study. AIMS Microbiology, 5(1), 1-18. doi:10.3934/microbiol.2019.1.1

Academic Publication

2019

Successful Treatment of Fulminant Clostridioides difficile Infection with Emergent Fecal Microbiota Transplantation in a Patient with Acute Myeloid Leukemia and Prolonged, Severe Neutropenia external link icon Opens a new window

Lee, M., Ramakrishna, B., Moss, A., Gold, H., & Branch‚ÄźElliman, W. (2019). Successful Treatment of Fulminant Clostridioides difficile Infection with Emergent Fecal Microbiota Transplantation in a Patient with Acute Myeloid Leukemia and Prolonged, Severe Neutropenia.¬†Transplant Infectious Disease. doi:10.1111/tid.13216

Academic Publication

2019

Fulminant Clostridium difficile Infection Cured by Fecal Microbiota Transplantation in a Bone Marrow Transplant Recipient With Critical Neutropenia external link icon Opens a new window

Krajicek, E., Bohm, M., Sagi, S., & Fischer, M. (2019). Fulminant Clostridium difficile Infection Cured by Fecal Microbiota Transplantation in a Bone Marrow Transplant Recipient With Critical Neutropenia. ACG Case Reports Journal, 6(8), e00198. doi:10.14309/crj.0000000000000198

Academic Publication

2019

Rapid Detection of Clostridium difficile Toxins in Stool by Raman Spectroscopy external link icon Opens a new window

Koya, S., Yurgelevic, S., Brusatori, M., Huang, C., Diebel, L., & Auner, G. (2019). Rapid Detection of Clostridium difficile Toxins in Stool by Raman Spectroscopy. Journal Of Surgical Research, 244, 111-116. doi:10.1016/j.jss.2019.06.039

Academic Publication

2019

Framework for rational donor selection in fecal microbiota transplant clinical trials external link icon Opens a new window

Duvallet, C., Zellmer, C., Panchal, P., Budree, S., Osman, M., & Alm, E. (2019). Framework for rational donor selection in fecal microbiota transplant clinical trials. doi:10.1101/19000307

Academic Publication

2019

Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial external link icon Opens a new window

Aroniadis, O., Brandt, L., Oneto, C., Feuerstadt, P., Sherman, A., & Wolkoff, A. et al. (2019). Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial. The Lancet Gastroenterology & Hepatology. doi:10.1016/s2468-1253(19)30198-0

Academic Publication

2020

Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: a retrospective cohort study external link icon Opens a new window

Vendrik, K., Terveer, E., Kuijper, E., Nooij, S., Boeije-Koppenol, E., & Sanders, I. et al. (2020). Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: a retrospective cohort study. The Lancet Infectious Diseases. doi: 10.1016/s1473-3099(20)30473-4

Academic Publication

2020

Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade external link icon Opens a new window

SahBandar, I., Chew, G., Corley, M., Pang, A., Tsai, N., & Hanks, N. et al. (2020). Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade. AIDS, 34(10), 1451-1460. doi: 10.1097/qad.0000000000002557

Academic Publication

2020

Modelling donor screening strategies to reduce the risk of SARS-CoV-2 transmission via fecal microbiota transplantation external link icon Opens a new window

Olesen, S., Zaman, A., Osman, M., & Ramakrishna, B. (2020). Modelling donor screening strategies to reduce the risk of SARS-CoV-2 transmission via fecal microbiota transplantation. Open Forum Infectious Diseases. doi: 10.1093/ofid/ofaa499

Academic Publication

2020

Global disparities in faecal microbiota transplantation research external link icon Opens a new window

Olesen, S., Panchal, P., Chen, J., Budree, S., & Osman, M. (2020). Global disparities in faecal microbiota transplantation research. The Lancet Gastroenterology & Hepatology, 5(3), 241. doi:10.1016/s2468-1253(19)30452-2

Academic Publication

2020

Gut microbial dysbiosis in individuals with Sjögren’s syndrome external link icon Opens a new window

Mendez, R., Watane, A., Farhangi, M., Cavuoto, K., Leith, T., & Budree, S. et al. (2020). Gut microbial dysbiosis in individuals with Sjögren’s syndrome. Microbial Cell Factories, 19(1). doi:10.1186/s12934-020-01348-7

Academic Publication

2020

Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro external link icon Opens a new window

Mahalak, K., Firrman, J., Lee, J., Bittinger, K., Nunez, A., Mattei, L., Zhang, H., Fett, B., Bobokalonov, J., Arango-Argoty, G., Zhang, G., Zhang, G., Liu, Lin. (2020) Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro. PLONE ONE. 15(6): e0234046. https://doi.org/10.1371/journal. pone.0234046

Academic Publication

2020

The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients external link icon Opens a new window

Lötstedt B, Boyer D, Visner G, Freiberger D, Lurie M, Kane M, DiFilippo C, Lundeberg J, Narvaez-Rivas M, Setchell K, Alm E, Rosen R. The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients. J Heart Lung Transplant. 2020 Dec 5:S1053-2498(20)31860-X. doi: 10.1016/j.healun.2020.11.013. Epub ahead of print. PMID: 33349521.

Academic Publication

2020

Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel external link icon Opens a new window

Ianiro, G., Mullish, B., Kelly, C., Sokol, H., Kassam, Z., & Ng, S. et al. (2020). Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel. The Lancet Gastroenterology & Hepatology. doi:10.1016/s2468-1253(20)30082-0

Academic Publication

2020

Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic external link icon Opens a new window

Ianiro, G., Mullish, B., Kelly, C., Kassam, Z., Kuijper, E., & Ng, S. et al. (2020). Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic. Gut, gutjnl-2020-321829. doi: 10.1136/gutjnl-2020-321829

Academic Publication

2020

Beyond fecal microbiota transplantation: Developing drugs from the microbiome external link icon Opens a new window

Gerardin Y, Timberlake S, Allegretti JR, Smith MB, Kassam Z. Beyond fecal microbiota transplantation: Developing drugs from the microbiome. J Infect Dis. 2020 Dec 17:jiaa700. doi: 10.1093/infdis/jiaa700. Epub ahead of print. PMID: 33330910.

Academic Publication

2020

Use of Fecal Microbial Transplantation for Immune Checkpoint Inhibitor Colitis external link icon Opens a new window

Fasanello, M., Robillard, K., Boland, P., Bain, A., & Kanehira, K. (2020). Use of Fecal Microbial Transplantation for Immune Checkpoint Inhibitor Colitis. ACG Case Reports Journal, 7(4), e00360. doi: 10.14309/crj.0000000000000360

Academic Publication

2021

An omics-based framework for assessing the health risk of antimicrobial resistance genes external link icon Opens a new window

Zhang AN, Gaston JM, Dai CL, Zhao S, Poyet M, Groussin M, Yin X, Li LG, van Loosdrecht MCM, Topp E, Gillings MR, Hanage WP, Tiedje JM, Moniz K, Alm EJ, Zhang T. An omics-based framework for assessing the health risk of antimicrobial resistance genes. Nat Commun. 2021 Aug 6;12(1):4765. doi: 10.1038/s41467-021-25096-3. PMID: 34362925.

Academic Publication

2021

Carriage rates of multidrug-resistant organisms among prospective stool donors external link icon Opens a new window

Zaman A, Qazi T, Pai P, Peters P, Nicolaysen S, Olesen SW. Carriage rates of multidrug-resistant organisms among prospective stool donors. Lancet Infect Dis. 2021 Apr;21(4):454-455. doi: 10.1016/S1473-3099(21)00091-8. PMID: 33773125.

Academic Publication

2021

Fecal microbiota transplantation in HIV: A pilot placebo-controlled study external link icon Opens a new window

Serrano-Villar S, Talavera-Rodríguez A, Gosalbes MJ, Madrid N, Pérez-Molina JA, Elliott RJ, Navia B, Lanza VF, Vallejo A, Osman M, Dronda F, Budree S, Zamora J, Gutiérrez C, Manzano M, Vivancos MJ, Ron R, Martínez-Sanz J, Herrera S, Ansa U, Moya A, Moreno S. Fecal microbiota transplantation in HIV: A pilot placebo-controlled study. Nat Commun. 2021 Feb 18;12(1):1139. doi: 10.1038/s41467-021-21472-1. PMID: 33602945.

Academic Publication

2021

16S rRNA sequencing of samples from universal stool bank donors external link icon Opens a new window

Santiago M, Olesen SW. 16S rRNA sequencing of samples from universal stool bank donors. BMC Res Notes. 2021 Mar 23;14(1):108. doi: 10.1186/s13104-021-05520-z. PMID: 33757553; PMCID: PMC7988957

Academic Publication

2021

SARS-CoV-2 vaccines and donor recruitment for FMT external link icon Opens a new window

Ianiro G, Mullish BH, Hvas CL, Segal JP, Kuijper EJ, Costello SP, Kelly CR, Allegretti JR, Fischer M, Iqbal TH, Satokari R, Kao D, van Prehn J, Ng SC, Bibbò S, Baunwall SMD, Quraishi MN, Sokol H, Zhang F, Keller J, Masucci L, Quaranta G, Kassam Z, Sanguinetti M, Tilg H, Gasbarrini A, Cammarota G. SARS-CoV-2 vaccines and donor recruitment for FMT. Lancet Gastroenterol Hepatol. 2021 Feb 8:S2468-1253(21)00032-7. doi: 10.1016/S2468-1253(21)00032-7. Epub ahead of print. PMID: 33571456.

Academic Publication

2021

Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation external link icon Opens a new window

Fujimoto K, Kimura Y, Allegretti JR, Yamamoto M, Zhang YZ, Katayama K, Tremmel G, Kawaguchi Y, Shimohigoshi M, Hayashi T, Uematsu M, Yamaguchi K, Furukawa Y, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation. Gastroenterology. 2021 Feb 9:S0016-5085(21)00400-5. doi: 10.1053/j.gastro.2021.02.013. Epub ahead of print. PMID: 33577875.

Academic Publication

2021

Progressive Shifts in the Gut Microbiome Reflect Prediabetes and Diabetes Development in a Treatment-Naive Mexican Cohort external link icon Opens a new window

Diener, C., Reyes-Escogido, M., Jimenez-Ceja, L., Matus, M., Gomez-Navarro, C., & Chu, N. et al. (2021). Progressive Shifts in the Gut Microbiome Reflect Prediabetes and Diabetes Development in a Treatment-Naive Mexican Cohort. Frontiers In Endocrinology, 11. doi: 10.3389/fendo.2020.602326

Academic Publication

2021

Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes external link icon Opens a new window

Aggarwala V, Mogno I, Li Z, Yang C, Britton GJ, Chen-Liaw A, Mitcham J, Bongers G, Gevers D, Clemente JC, Colombel JF, Grinspan A, Faith J. Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes. Nat Microbiol. 2021 Oct;6(10):1309-1318. doi: 10.1038/s41564-021-00966-0. Epub 2021 Sep 27. PMID: 34580445.

Academic Publication

2022

Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye external link icon Opens a new window

Watane A, Cavuoto KM, Rojas M, Dermer H, Day JO, Banerjee S, Galor A. Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye. Am J Ophthalmol. 2022 Jan;233:90-100. doi: 10.1016/j.ajo.2021.06.022. Epub 2021 Jun 30. PMID: 34214453; PMCID: PMC8678170.

Academic Publication

2022

Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report external link icon Opens a new window

Beglinger C, Borgwardt S, Raes J, Schmidt A, Lang UE. Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report. Front Psychiatry. 2022 Feb 17;13:815422. doi: 10.3389/fpsyt.2022.815422. PMID: 35250668; PMCID: PMC8891755.

Academic Publication

2017

Does fecal microbiota transplantation from an obese donor lead to weight gain? A case series of 70 recipients external link icon Opens a new window

Fischer, M., Sipe, B., Torbeck, M., Xu, H., Kassam, Z., & Allegretti, J. R. (2017). Does fecal microbiota transplantation from an obese donor lead to weight gain? A case series of 70 recipients. Gastroenterology, 152(5), S1004.

Academic Publication

2019

Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients external link icon Opens a new window

Allegretti, J., Kassam, Z., Mullish, B., Chiang, A., Carrellas, M., & Hurtado, J. et al. (2019). Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients. Clinical Gastroenterology And Hepatology. doi:10.1016/j.cgh.2019.07.006

Academic Publication

2020

Fecal microbiota transplantation improves metabolic syndrome parameters: systematic review with meta-analysis based on randomized clinical trials external link icon Opens a new window

Proença IM, Allegretti JR, Bernardo WM, de Moura DTH, Ponte Neto AM, Matsubayashi CO, Flor MM, Kotinda APST, de Moura EGH. Fecal microbiota transplantation improves metabolic syndrome parameters: systematic review with meta-analysis based on randomized clinical trials. Nutr Res. 2020 Nov;83:1-14. doi: 10.1016/j.nutres.2020.06.018. Epub 2020 Jul 3. PMID: 32987284.

Academic Publication

2021

Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity external link icon Opens a new window

Allegretti JR, Kassam Z, Hurtado J, Marchesi JR, Mullish BH, Chiang A, Thompson CC, Cummings BP. Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity. Hormones (Athens). 2021 Jan 9. doi: 10.1007/s42000-020-00265-z. Epub ahead of print. PMID: 33420959.

Academic Publication

2017

The Gut Microbiome in Autoimmune Hepatitis Links to Disease Progression and is Significantly Different from Lupus and Healthy Controls external link icon Opens a new window

Kumar, V., Vieira, S. M., Ruff, W., Dehner, C., Kassam, Z., Boyer, J. L., ... & Kriegel, M. (2017, October). The Gut Microbiome in Autoimmune Hepatitis Links to Disease Progression and is Significantly Different from Lupus and Healthy Controls. HEPATOLOGY (Vol. 66, pp. 189A-189A).

Academic Publication

2017

Fecal microbiota transplant using a precision medicine approach is safe, associated with lower hospitalization risk and improved cognitive function in recurrent hepatic encephalopathy external link icon Opens a new window

Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E., Liu, E. J., Kheradman, R., ... & Alm, E. (2017). Fecal microbiota transplant using a precision medicine approach is safe, Associated with lower hospitalization risk and improved cognitive function in recurrent hepatic encephalopathy. Gastroenterology, 152(5), S906.

Academic Publication

2017

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial external link icon Opens a new window

Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., ... & Williams, R. (2017). Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Hepatology.

Academic Publication

2018

Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant external link icon Opens a new window

Bajaj, J. S., Kakiyama, G., Savage, T., Takei, H, Kassam, Z. A., Fagan, A., ‚Ķ & Gillevet, P. M. (2018). Antibiotic‚ÄźAssociated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant. Hepatology, 68: 1549-1558.

Academic Publication

2019

Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‚ÄźControlled Trial external link icon Opens a new window

Bajaj, J., Salzman, N., Acharya, C., Sterling, R., White, M., & Gavis, E. et al. (2019). Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‚ÄźControlled Trial.¬†Hepatology,¬†70(5), 1690-1703. doi:10.1002/hep.30690

Academic Publication

2019

Long-term Outcomes after Fecal Microbiota Transplant in Cirrhosis external link icon Opens a new window

Bajaj, JS., Fagan, A., Gavis, EA., Kassam, Z., Sikaroodi, M., Gillevet, P. (2019). Long term outcomes after Fecal Microbiota Transplant in Cirrhosis. Gastroenterology, doi: https://doi.org/10.1053/j.gastro.2019.01.033

Academic Publication

2019

Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial external link icon Opens a new window

Allegretti, J., Kassam, Z., Carrellas, M., Mullish, B., Marchesi, J., & Pechlivanis, A. et al. (2019). Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis. The American Journal Of Gastroenterology, 1. doi:10.14309/ajg.0000000000000115

Academic Publication

2020

Fecal Microbiota Transplantation is Safe and Effective in Patients with Clostridioides difficile Infection and Cirrhosis external link icon Opens a new window

Cheng YW, Alhaffar D, Saha S, et al. Fecal Microbiota Transplantation is Safe and Effective in Patients with Clostridioides difficile Infection and Cirrhosis [published online ahead of print, 2020 Jul 6]. Clin Gastroenterol Hepatol. 2020;S1542-3565(20)30915-0. doi:10.1016/j.cgh.2020.06.051

Academic Publication

2020

Fecal Microbiota Transplant in Cirrhosis Reduces Gut Microbial Antibiotic Resistance Genes: Analysis of Two Trials external link icon Opens a new window

Bajaj JS, Shamsaddini A, Fagan A, Sterling RK, Gavis E, Khoruts A, Fuchs M, Lee H, Sikaroodi M, Gillevet PM. Fecal Microbiota Transplant in Cirrhosis Reduces Gut Microbial Antibiotic Resistance Genes: Analysis of Two Trials. Hepatol Commun. 2020 Nov 21;5(2):258-271. doi: 10.1002/hep4.1639. PMID: 33553973; PMCID: PMC7850310.

Academic Publication

2020

Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‚ÄźControlled Trial external link icon Opens a new window

Bajaj, J., Salzman, N., Acharya, C., Sterling, R., White, M., & Gavis, E. et al. (2019). Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‚ÄźControlled Trial.¬†Hepatology,¬†70(5), 1690-1703. doi: 10.1002/hep.30690

Academic Publication

2020

Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis external link icon Opens a new window

Bajaj JS, Khoruts A. Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis. J Hepatol. 2020 May;72(5):1003-1027. doi: 10.1016/j.jhep.2020.01.017. Epub 2020 Jan 28. PMID: 32004593.

Academic Publication

2020

A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder external link icon Opens a new window

Bajaj, J., Gavis, E., Fagan, A., Wade, J., Thacker, L., & Fuchs, M. et al. (2020). A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder. Hepatology. doi: 10.1002/hep.31496

Academic Publication

2020

Chronic Liver Diseases and the Microbiome: Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease external link icon Opens a new window

Acharya C, Bajaj JS. Chronic Liver Diseases and the Microbiome: Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease. Gastroenterology. 2020 Nov 27:S0016-5085(20)35504-9. doi: 10.1053/j.gastro.2020.10.056. Epub ahead of print. PMID: 33253686.

Academic Publication

2016

Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease external link icon Opens a new window

Fischer, M., Kao, D., Kelly, C., Kuchipudi, A., Jafri, S. M., Blumenkehl, M., ... & Cook, G. (2016). Fecal microbiota transplantation is safe and efficacious for recurrent or refractory Clostridium difficile infection in patients with inflammatory bowel disease. Inflammatory bowel diseases, 22(10), 2402-2409.

Academic Publication

2017

The Risk of Inflammatory Bowel Disease Flares after Fecal Microbiota Transplantation: Systematic Review and Meta-Analysis external link icon Opens a new window

Qazi, T., Amaratunga, T., Barnes, E. L., Fischer, M., Kassam, Z., & Allegretti, J. R. (2017). The risk of inflammatory bowel disease flares after fecal microbiota transplantation: Systematic review and meta-analysis. Gut microbes, 8(6), 574-588.

Academic Publication

2017

Fecal microbiota transplantation differentially influences the gut microbiota of Clostridium difficile infection and ileal pouch anal anastomosis patients external link icon Opens a new window

Piceno, Y. M., El-Nachef, N., Kassam, Z., Smith, M., Lynch, K., Zydek, M., ... & Lynch, S. (2017). Fecal Microbiota Transplantation Differentially Influences the Gut Microbiota of Clostridium Difficile Infection and Ileal Pouch Anal Anastomosis Patients. Gastroenterology, 152(5), S1006.

Academic Publication

2017

Systematic Review and Meta-Analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis external link icon Opens a new window

Narula, N., Kassam, Z., Yuan, Y., Colombel, J. F., Ponsioen, C., Reinisch, W., & Moayyedi, P. (2017). Systematic review and meta-analysis: Fecal microbiota transplantation for treatment of active ulcerative colitis. Inflammatory bowel diseases, 23(10), 1702-1709.

Academic Publication

2017

A Surgical Clostridium-associated Risk of Death Score Predicts Mortality after Colectomy for Clostridium difficile external link icon Opens a new window

Kulaylat, A. S., Kassam, Z., Hollenbeak, C. S., & Stewart Sr, D. B. (2017). A Surgical Clostridium-Associated Risk of Death Score Predicts Mortality After Colectomy for Clostridium difficile. Diseases of the Colon & Rectum, 60(12), 1285-1290.

Academic Publication

2017

Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis external link icon Opens a new window

Jacob, V., Crawford, C., Cohen-Mekelburg, S., Viladomiu, M., Putzel, G. G., Schneider, Y., ... & Ajami, N. J. (2017). Single delivery of high-diversity fecal microbiota preparation by colonoscopy is safe and effective in increasing microbial diversity in active ulcerative colitis. Inflammatory bowel diseases, 23(6), 903-911.

Academic Publication

2017

Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease external link icon Opens a new window

Fischer, M., Bittar, M., Papa, E., Kassam, Z., & Smith, M. (2017). Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease. Gut microbes, 8(3), 205-207.

Academic Publication

2017

Fecal microbiota transplantation is safe and effective in chronic pouchitis patients external link icon Opens a new window

El-Nachef, N., Piceno, Y. M., Kassam, Z., Zydek, M., Ablaza, A. J., Leith, T., ... & Lynch, S. (2017). Fecal Microbiota Transplantation is Safe and Effective in Chronic Pouchitis Patients. Gastroenterology, 152(5), S1009.

Academic Publication

2017

The role of fecal microbiota transplantation in ulcerative colitis and Crohn’s disease: results from a parallel inflammatory bowel disease cohort study external link icon Opens a new window

El-Nachef, N., Piceno, Y. M., Kassam, Z., Ablaza, A. J., Zydek, M., Lynch, K., ... & Lynch, S. (2017). The Role of Fecal Microbiota Transplantation in Ulcerative Colitis and Crohn's Disease: Results from a Parallel Inflammatory Bowel Disease Cohort Study. Gastroenterology, 152(5), S1008.

Academic Publication

2017

Does Rifaximin prior to fecal microbiota transplantation improve clinical outcomes compared to microbiome restoration alone in ulcerative colitis? A cohort study evaluating the impact of non-absorbable antibiotic pretreatment external link icon Opens a new window

El-Nachef, N., Kassam, Z., Piceno, Y. M., Ablaza, A. J., Zydek, M., Elliott, R. J., ... & Somsouk, M. (2017). Does Rifaximin Prior to Fecal Microbiota Transplantation Improve Clinical Outcomes Compared to Microbiome Restoration Alone in Ulcerative Colitis? a Cohort Study Evaluating the Impact of Non-Absorbable Antibiotic Pretreatment. Gastroenterology, 152(5), S1008-S1009.

Academic Publication

2017

Differences in Clinical Course, Genetics, and the Microbiome Between Familial and Sporadic Inflammatory Bowel Diseases external link icon Opens a new window

Borren, N. Z., Conway, G., Garber, J. J., Khalili, H., Budree, S., Mallick, H., ... & Ananthakrishnan, A. N. (2017). Differences in Clinical Course, Genetics, and the Microbiome Between Familial and Sporadic Inflammatory Bowel Diseases. Journal of Crohn's and Colitis, 12(5), 525-531.

Academic Publication

2017

The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present and Future external link icon Opens a new window

Allegretti, J., Eysenbach, L. M., El-Nachef, N., Fischer, M., Kelly, C., & Kassam, Z. (2017). The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present, and Future. Inflammatory bowel diseases, 23(10), 1710-1717.

Academic Publication

2018

Advances in mesenchymal stromal cell therapy in the management of Crohn's disease external link icon Opens a new window

Ibraheim, H., Giacomini, C., Kassam, Z., Dazzi, F., & Powell, N. (2018). Advances in mesenchymal stromal cell therapy in the management of Crohn’s disease. Expert review of Gastroenterology & Hepatology, 12(2), 141-153.

Academic Publication

2019

Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study external link icon Opens a new window

Selvig, D., Piceno, Y., Terdiman, J., Zydek, M., Umetsu, S., & Balitzer, D. et al. (2019). Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study. Digestive Diseases And Sciences. doi:10.1007/s10620-019-05715-2

Academic Publication

2019

Combined Endoscopic and Oral Fecal Microbiota Transplantation in Patients with Antibiotic-Dependent Pouchitis: Low Clinical Efficacy due to Low Donor Microbial Engraftment external link icon Opens a new window

Herfarth, H., Barnes, E. L., Long, M. D., Isaacs, K. L., Leith, T., Silverstein, M., ‚Ķ Kassam, Z. (2019). Combined Endoscopic and Oral Fecal Microbiota Transplantation in Patients with Antibiotic-Dependent Pouchitis: Low Clinical Efficacy due to Low Donor Microbial Engraftment. Inflammatory Intestinal Diseases, 1‚Äď6. doi:10.1159/000497042

Academic Publication

2019

Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile external link icon Opens a new window

Gutin, L., Piceno, Y., Fadrosh, D., Lynch, K., Zydek, M., & Kassam, Z. et al. (2019). Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile. United European Gastroenterology Journal, 7(6), 807-814. doi:10.1177/2050640619845986

Academic Publication

2019

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. external link icon Opens a new window

Gogokhia, L., Buhrke, K., Bell, R., Hoffman, B., Brown, D., & Hanke-Gogokhia, C. et al. (2019). Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell Host & Microbe, 25(2), 285-299.e8. doi:10.1016/j.chom.2019.01.008

Academic Publication

2020

Re-Evaluating the Evidence for Faecal Microbiota Transplantation ‚ÄėSuper-Donors‚Äô in Inflammatory Bowel Disease external link icon Opens a new window

Olesen, S., & Gerardin, Y. (2020). Re-Evaluating the Evidence for Faecal Microbiota Transplantation ‚ÄėSuper-Donors‚Äô in Inflammatory Bowel Disease.¬†Journal Of Crohn's And Colitis,¬†15(3), 453-461. doi: 10.1093/ecco-jcc/jjaa170

Academic Publication

2020

Fecal transplantation for ulcerative colitis: current evidence and future applications external link icon Opens a new window

Loris R. Lopetuso, Gianluca Ianiro, Jessica R. Allegretti, Stefano Bibbò, Antonio Gasbarrini, Franco Scaldaferri & Giovanni Cammarota (2020) Fecal transplantation for ulcerative colitis: current evidence and future applications. Expert Opinion on Biological Therapy, 20(3). DOI: 10.1080/14712598.2020.1733964

Academic Publication

2020

Fecal Microbiota Transplantation for Ulcerative Colitis. Are We Ready for Primetime? external link icon Opens a new window

Cheng, Y., & Fischer, M. (2020). Fecal Microbiota Transplantation for Ulcerative Colitis. Are We Ready for Primetime?. Gastroenterology Clinics Of North America, 49(4), 739-752. doi: 10.1016/j.gtc.2020.08.006

Academic Publication

2020

Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection external link icon Opens a new window

Allegretti, J., Kelly, C., Grinspan, A., Mullish, B., Kassam, Z., & Fischer, M. (2020). Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection. Gastroenterology, 159(5), 1982-1984. doi: 10.1053/j.gastro.2020.07.045

Academic Publication

2020

Inflammatory Bowel Disease Outcomes Following Fecal Microbiota Transplantation for Recurrent C. difficile Infection external link icon Opens a new window

Allegretti JR, Kelly CR, Grinspan A, Mullish BH, Hurtado J, Carrellas M, Marcus J, Marchesi JR, McDonald JAK, Gerardin Y, Silverstein M, Pechlivanis A, Barker GF, Miguens Blanco J, Alexander JL, Gallagher KI, Pettee W, Phelps E, Nemes S, Sagi SV, Bohm M, Kassam Z, Fischer M. Inflammatory Bowel Disease Outcomes Following Fecal Microbiota Transplantation for Recurrent C. difficile Infection. Inflamm Bowel Dis. 2020 Nov 6:izaa283. doi: 10.1093/ibd/izaa283. Epub ahead of print. PMID: 33155639.

Academic Publication

2021

Transferable IgA-coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation external link icon Opens a new window

Lima S, Gogokhia L, Viladomiu M, Chou L, Putzel G, Jin W, Pires S, Guo CJ, Gerardin Y, Crawford CV, Jacob V, Scherl E, Brown SE, Hambor J, Longman R. Transferable IgA-coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation. Gastroenterology. 2021 Oct 1:S0016-5085(21)03610-6. doi: 10.1053/j.gastro.2021.09.061. Epub ahead of print. PMID: 34606847.

Academic Publication

2021

Fecal Microbiota Transplantation for Chronic Pouchitis: Promising Novel Therapeutic or Lost Cause? external link icon Opens a new window

Dalal RS, Allegretti JR. Fecal Microbiota Transplantation for Chronic Pouchitis: Promising Novel Therapeutic or Lost Cause? Inflamm Bowel Dis. 2021 Jan 27:izab002. doi: 10.1093/ibd/izab002. Epub ahead of print. PMID: 33501941.

Academic Publication

2021

Diagnosis and management of Clostridioides difficile infection in patients with inflammatory bowel disease external link icon Opens a new window

Dalal RS, Allegretti JR. Diagnosis and management of Clostridioides difficile infection in patients with inflammatory bowel disease. Curr Opin Gastroenterol. 2021 Mar 3. doi: 10.1097/MOG.0000000000000739. Epub ahead of print. PMID: 33654015.

Academic Publication

2021

Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: results of a single-center, prospective, randomized pilot study external link icon Opens a new window

Crothers JW, Chu ND, Nguyen LTT, Phillips M, Collins C, Fortner K, Del Rio-Guerra R, Lavoie B, Callas P, Velez M, Cohn A, Elliott RJ, Wong WF, Vo E, Wilcox R, Smith M, Kassam Z, Budd R, Alm EJ, Mawe GM, Moses PL. Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: results of a single-center, prospective, randomized pilot study. BMC Gastroenterol. 2021 Jul 8;21(1):281. doi: 10.1186/s12876-021-01856-9. PMID: 34238227; PMCID: PMC8268596.

Academic Publication

2021

Fecal microbial transplant for inflammatory bowel disease external link icon Opens a new window

Claytor JD, El-Nachef N. Fecal microbial transplant for inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2020 Sep;23(5):355-360. doi: 10.1097/MCO.0000000000000676. PMID: 32618725.

Academic Publication

2021

Fecal Microbiota Transplantation for the Treatment of Ulcerative Colitis: A Qualitative Assessment of Patient Perceptions and Experiences external link icon Opens a new window

Chauhan U, Popov J, Farbod Y, Kalantar M, Wolfe M, Moayyedi P, Marshall JK, Halder S, Kaasalainen S. Fecal Microbiota Transplantation for the Treatment of Ulcerative Colitis: A Qualitative Assessment of Patient Perceptions and Experiences. J Can Assoc Gastroenterol. 2021 Mar 26;4(6):e120-e129. doi: 10.1093/jcag/gwab007. PMID: 34877470; PMCID: PMC8643654.

Academic Publication

2022

Effect of antibiotic pretreatment on bacterial engraftment after Fecal Microbiota Transplant (FMT) in IBS-D external link icon Opens a new window

Singh P, Alm EJ, Kelley JM, Cheng V, Smith M, Kassam Z, Nee J, Iturrino J, Lembo A. Effect of antibiotic pretreatment on bacterial engraftment after Fecal Microbiota Transplant (FMT) in IBS-D. Gut Microbes. 2022 Jan-Dec;14(1):2020067. doi: 10.1080/19490976.2021.2020067. PMID: 35014601; PMCID: PMC8757476.

Academic Publication

2022

Dynamic Colonization of Microbes and Their Functions after Fecal Microbiota Transplantation for Inflammatory Bowel Disease external link icon Opens a new window

Chu ND, Crothers JW, Nguyen LTT, Kearney SM, Smith MB, Kassam Z, Collins C, Xavier R, Moses PL, Alm EJ. Dynamic Colonization of Microbes and Their Functions after Fecal Microbiota Transplantation for Inflammatory Bowel Disease. mBio. 2021 Aug 31;12(4):e0097521. doi: 10.1128/mBio.00975-21. Epub 2021 Jul 20. PMID: 34281401; PMCID: PMC8406238.

Academic Publication

2017

Does fecal microbiota transplantation from an obese donor lead to weight gain? A case series of 70 recipients external link icon Opens a new window

Fischer, M., Sipe, B., Torbeck, M., Xu, H., Kassam, Z., & Allegretti, J. R. (2017). Does fecal microbiota transplantation from an obese donor lead to weight gain? A case series of 70 recipients. Gastroenterology, 152(5), S1004

Academic Publication

2017

Stool Donor Body Mass Index Does Not Affect Recipient Weight After a Single Fecal Microbiota Transplantation for Clostridium difficile Infection external link icon Opens a new window

Fischer, M., Kao, D., Kassam, Z., Smith, J., Louie, T., Sipe, B., ... & Allegretti, J. R. (2017). Stool Donor Body Mass Index Does Not Affect Recipient Weight After a Single Fecal Microbiota Transplantation for C. difficile Infection. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association.

Academic Publication

2017

Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease external link icon Opens a new window

Fischer, M., Bittar, M., Papa, E., Kassam, Z., & Smith, M. (2017). Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease. Gut microbes, 8(3), 205-207.

Academic Publication

2017

Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors external link icon Opens a new window

Budree, S., Wong, W. F., Tu, E., Rao, S., Allegretti, J. R., Fischer, M., ... & Kassam, Z. (2017). Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors. Gastroenterology, 152(5), S349.

Academic Publication

2017

The association of stool donor diet on microbial profile and clinical outcomes of fecal microbiota transplantation in clostridium difficile infection external link icon Opens a new window

Budree, S., Tu, E., Leith, T., Allegretti, J. R., Rao, S., Day, R., ... & Osman, M. (2017). The Association of Stool Donor Diet on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630-S631.

Academic Publication

2017

The association of donor stool consistency by Bristol stool scale on microbial profile and clinical outcomes of fecal microbiota transplantation in Clostridium difficile infection external link icon Opens a new window

Budree, S., Rao, S., Allegretti, J. R., Fischer, M., Kelly, C. R., Smith, M., ... & Kassam, Z. (2017). The Association of Donor Stool Consistency by Bristol Stool Scale on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630.

Academic Publication

2017

Donor stool processing time: the effect on the intestinal microbiome and clinical outcomes of fecal microbiota transplantation in Clostridium difficile Infection external link icon Opens a new window

Budree, S., Elliott, R. J., Rao, S., Njenga, M., Ladha, A., Allegretti, J. R., ... & Kassam, Z. (2017). Donor Stool Processing Time: The Effect on the Intestinal Microbiome and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S1006.

Academic Publication

2017

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial external link icon Opens a new window

Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., ... & Williams, R. (2017). Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Hepatology.

Academic Publication

2018

Does the Donor Matter? Microbiome Sequencing to Evaluate Lower Donor Efficacy in Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection external link icon Opens a new window

Osman, M., Abend, A., Panchal, P., Kassam, Z., & Budree, S. (2018). 88-Does the Donor Matter? Microbiome Sequencing to Evaluate Lower Donor Efficacy in Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection. Gastroenterology, 154(6), S-25.

Academic Publication

2018

Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality external link icon Opens a new window

Barnes, D., Ng, K., Smits, S., Sonnenburg, J., Kassam, Z., & Park, K. T. (2018). Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality. Journal of pediatric gastroenterology and nutrition.

Academic Publication

2019

Donor Screening for Fecal Microbiota Transplantation external link icon Opens a new window

Kassam Z, et al. (2019). Donor Screening for Fecal Microbiota Transplantation. NEJM. doi: 10.1056/NEJMc1913670.

Academic Publication

2020

Re-Evaluating the Evidence for Faecal Microbiota Transplantation ‚ÄėSuper-Donors‚Äô in Inflammatory Bowel Disease external link icon Opens a new window

Olesen, S., & Gerardin, Y. (2020). Re-Evaluating the Evidence for Faecal Microbiota Transplantation ‚ÄėSuper-Donors‚Äô in Inflammatory Bowel Disease.¬†Journal Of Crohn's And Colitis,¬†15(3), 453-461. doi: 10.1093/ecco-jcc/jjaa170

Academic Publication

2020

Challenges of Screening Prospective Stool Donors for Fecal Microbiota Transplantation external link icon Opens a new window

Dubois, N., Read, C., O’Brien, K., and Ling, K. (2020). Biological Research For Nursing. Challenges of Screening Prospective Stool Donors for Fecal Microbiota Transplantation. Retrieved from https://journals.sagepub.com/doi/abs/10.1177/1099800420941185

Academic Publication

2014

OpenBiome remains open to serve the medical community external link icon Opens a new window

Smith, M., Kassam, Z., Edelstein, C., Burgess, J., Alm, E., & Ratner, M. et al. (2014). OpenBiome remains open to serve the medical community. Nature Biotechnology.

Academic Publication

2014

Policy: How to regulate faecal transplants external link icon Opens a new window

Smith, M., Kelly, C., & Alm, E. (2014). Policy: How to regulate faecal transplants. Nature, 506(7488), 290-291. doi:10.1038/506290a

Academic Publication

2015

Ensuring the safe and effective FDA regulation of fecal microbiota transplantation external link icon Opens a new window

Sachs, R., & Edelstein, C. (2015). Ensuring the safe and effective FDA regulation of fecal microbiota transplantation. Journal of Law and the Biosciences. 2. 10.1093/jlb/lsv032.

Academic Publication

2015

Prospective Assessment of Donor Eligibility for Fecal Microbiota Transplantation at a Public Stool Bank: Results From the Evaluation of 1,387 Candidate Donors external link icon Opens a new window

Dubois, N., Ling, K., Osman, M., Burns, L., Mendolia, G., Blackler, D., Burgess, J., Edelstein, C., Noh, A., Vo, E., Alm E., Smith, M., and Kassam, Z. (2015). Prospective Assessment of Donor Eligibility for Fecal Microbiota Transplantation at a Public Stool Bank: Results From the Evaluation of 1,387 Candidate Donors. Idsa. Retrieved from https://idsa.confex.com/idsa/2015/webprogram/Paper52979.html

Academic Publication

2015

Seeking safe stool: Canada needs a universal donor model external link icon Opens a new window

Edelstein, C., Daw, J., & Kassam, Z. (2015). Seeking safe stool: Canada needs a universal donor model. Canadian Medical Association Journal, 188(17-18), E431-E432. doi:10.1503/cmaj.150672

Academic Publication

2016

Safety and Efficacy of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection From An International Public Stool Bank: Results From a 2050-Patient Multicenter Cohort external link icon Opens a new window

Osman, M., O'Brien, K., Stoltzner, Z., Ling, K., Koelsch, E., & Dubois, N. et al. (2016). Safety and Efficacy of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection From An International Public Stool Bank: Results From a 2050-Patient Multicenter Cohort. Open Forum Infectious Diseases, 3(suppl_1). doi:10.1093/ofid/ofw172.1668

Academic Publication

2016

Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease external link icon Opens a new window

Fischer, M., Kao, D., Kelly, C., Kuchipudi, A., Jafri, S. M., Blumenkehl, M., ... & Cook, G. (2016). Fecal microbiota transplantation is safe and efficacious for recurrent or refractory Clostridium difficile infection in patients with inflammatory bowel disease. Inflammatory bowel diseases, 22(10), 2402-2409.

Academic Publication

2017

Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals external link icon Opens a new window

Vujkovic-Cvijin, I., Rutishauser, R. L., Pao, M., Hunt, P. W., Lynch, S. V., McCune, J. M., & Somsouk, M. (2017). Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals. Gut microbes, 8(5), 440-450.

Academic Publication

2017

Faecal microbiota transplantation for Clostridium difficile infection: a multicentre study of non-responders external link icon Opens a new window

Razik, R., Osman, M., Lieberman, A., Allegretti, J. R., & Kassam, Z. (2017). Faecal microbiota transplantation for Clostridium difficile infection: a multicentre study of non-responders. N Engl J Med, 368, 407-415.

Academic Publication

2017

The Risk of Inflammatory Bowel Disease Flares after Fecal Microbiota Transplantation: Systematic Review and Meta-Analysis external link icon Opens a new window

Qazi, T., Amaratunga, T., Barnes, E. L., Fischer, M., Kassam, Z., & Allegretti, J. R. (2017). The risk of inflammatory bowel disease flares after fecal microbiota transplantation: Systematic review and meta-analysis. Gut microbes, 8(6), 574-588

Academic Publication

2017

Fecal microbiota transplantation differentially influences the gut microbiota of Clostridium difficile infection and ileal pouch anal anastomosis patients external link icon Opens a new window

Piceno, Y. M., El-Nachef, N., Kassam, Z., Smith, M., Lynch, K., Zydek, M., ... & Lynch, S. (2017). Fecal Microbiota Transplantation Differentially Influences the Gut Microbiota of Clostridium Difficile Infection and Ileal Pouch Anal Anastomosis Patients. Gastroenterology, 152(5), S1006.

Academic Publication

2017

Pediatric access to fecal microbiota transplantation for recurrent Clostridium difficile Infection in the United States and the impact of stool banks: a geospatial analysis external link icon Opens a new window

Panchal, P., Budree, S., Tu, E., Kahn, S. A., Allegretti, J. R., Fischer, M., ... & Osman, M. (2017). Pediatric Access to Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection in the United States and the Impact of Stool Banks: A Geospatial Analysis. Gastroenterology, 152(5), S849-S850.

Academic Publication

2017

Systematic Review and Meta-Analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis external link icon Opens a new window

Narula, N., Kassam, Z., Yuan, Y., Colombel, J. F., Ponsioen, C., Reinisch, W., & Moayyedi, P. (2017). Systematic review and meta-analysis: fecal microbiota transplantation for treatment of active ulcerative colitis. Inflammatory bowel diseases, 23(10), 1702-1709.

Academic Publication

2017

Prevalence of early antibiotic use post-fecal microbiota transplantation and corresponding risk of FMT failure. external link icon Opens a new window

Allegretti, J. R., Kao, D. H., Sitko, J., Fischer, M., & Kassam, Z. (2017). Prevalence of Early Antibiotic Use Post-Fecal Microbiotatransplantation and Corresponding Risk of FMT Failure. Gastroenterology, 152(5), S342-S343.

Academic Publication

2017

Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis external link icon Opens a new window

Jacob, V., Crawford, C., Cohen-Mekelburg, S., Viladomiu, M., Putzel, G. G., Schneider, Y., ... & Ajami, N. J. (2017). Single delivery of high-diversity fecal microbiota preparation by colonoscopy is safe and effective in increasing microbial diversity in active ulcerative colitis. Inflammatory bowel diseases, 23(6), 903-911.

Academic Publication

2017

Fecal microbiota transplant in severe and severe complicated Clostridium difficile: a promising treatment approach external link icon Opens a new window

Fischer, M., Sipe, B., Cheng, Y. W., Phelps, E., Rogers, N., Sagi, S., ... & Kassam, Z. (2017). Fecal microbiota transplant in severe and severe-complicated Clostridium difficile: A promising treatment approach. Gut microbes, 8(3), 289-302.

Academic Publication

2017

Fecal microbiota transplantation is safe and effective for the treatment of Clostridium difficile infection in solid organ transplant recipients external link icon Opens a new window

Fischer, M., Khan, M., Phelps, E. L., Safdar, N., Misch, E. A., Kaur, N., ... & Xu, H. (2017). Fecal Microbiota Transplantation is Safe and Effective for the Treatment of Clostridium Difficile Infection in Solid Organ Transplant Recipients. Gastroenterology, 152(5), S1005.

Academic Publication

2017

Stool Donor Body Mass Index Does Not Affect Recipient Weight After a Single Fecal Microbiota Transplantation for Clostridium difficile Infection external link icon Opens a new window

Fischer, M., Kao, D., Kassam, Z., Smith, J., Louie, T., Sipe, B., ... & Allegretti, J. R. (2017). Stool Donor Body Mass Index Does Not Affect Recipient Weight After a Single Fecal Microbiota Transplantation for C. difficile Infection. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association.

Academic Publication

2017

Should we recommend anti-Clostridium difficile antibiotic or probiotic prophylaxis? Risk of Clostridium difficile infection with systemic antimicrobial therapy following successful fecal microbiota transplant external link icon Opens a new window

Fischer, M., Kao, D. H., Phelps, E. L., Smith, J. D., Roach, B., Kassam, Z., ... & Allegretti, J. R. (2017). Should we Recommend Anti-Clostridium Difficile Antibiotic or Probiotic Prophylaxis?: Risk of Clostridium Difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant. Gastroenterology, 152(5), S1005.

Academic Publication

2017

Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease external link icon Opens a new window

Fischer, M., Bittar, M., Papa, E., Kassam, Z., & Smith, M. (2017). Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease. Gut microbes, 8(3), 205-207.

Academic Publication

2017

Fecal microbiota transplantation is safe and effective in chronic pouchitis patients external link icon Opens a new window

El-Nachef, N., Piceno, Y. M., Kassam, Z., Zydek, M., Ablaza, A. J., Leith, T., ... & Lynch, S. (2017). Fecal Microbiota Transplantation is Safe and Effective in Chronic Pouchitis Patients. Gastroenterology, 152(5), S1009.

Academic Publication

2017

The role of fecal microbiota transplantation in ulcerative colitis and Crohn’s disease: results from a parallel inflammatory bowel disease cohort study external link icon Opens a new window

El-Nachef, N., Piceno, Y. M., Kassam, Z., Ablaza, A. J., Zydek, M., Lynch, K., ... & Lynch, S. (2017). The Role of Fecal Microbiota Transplantation in Ulcerative Colitis and Crohn's Disease: Results from a Parallel Inflammatory Bowel Disease Cohort Study. Gastroenterology, 152(5), S1008.

Academic Publication

2017

Profiling Living Bacteria Informs Preparation of Fecal Microbiota Transplantations external link icon Opens a new window

Chu, N. D., Smith, M. B., Perrotta, A. R., Kassam, Z., & Alm, E. J. (2017). Profiling living bacteria informs preparation of fecal microbiota transplantations. PloS one, 12(1), e0170922.

Academic Publication

2017

Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors external link icon Opens a new window

Budree, S., Wong, W. F., Tu, E., Rao, S., Allegretti, J. R., Fischer, M., ... & Kassam, Z. (2017). Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors. Gastroenterology, 152(5), S349.

Academic Publication

2017

The association of stool donor diet on microbial profile and clinical outcomes of fecal microbiota transplantation in clostridium difficile infection external link icon Opens a new window

Budree, S., Tu, E., Leith, T., Allegretti, J. R., Rao, S., Day, R., ... & Osman, M. (2017). The Association of Stool Donor Diet on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630-S631.

Academic Publication

2017

The association of donor stool consistency by Bristol stool scale on microbial profile and clinical outcomes of fecal microbiota transplantation in Clostridium difficile infection external link icon Opens a new window

Budree, S., Rao, S., Allegretti, J. R., Fischer, M., Kelly, C. R., Smith, M., ... & Kassam, Z. (2017). The Association of Donor Stool Consistency by Bristol Stool Scale on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630.

Academic Publication

2017

Donor stool processing time: the effect on the intestinal microbiome and clinical outcomes of fecal microbiota transplantation in Clostridium difficile Infection external link icon Opens a new window

Budree, S., Elliott, R. J., Rao, S., Njenga, M., Ladha, A., Allegretti, J. R., ... & Kassam, Z. (2017). Donor Stool Processing Time: The Effect on the Intestinal Microbiome and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S1006.

Academic Publication

2017

Fecal microbiota transplant using a precision medicine approach is safe, associated with lower hospitalization risk and improved cognitive function in recurrent hepatic encephalopathy external link icon Opens a new window

Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E., Liu, E. J., Kheradman, R., ... & Alm, E. (2017). Fecal microbiota transplant using a precision medicine approach is safe, Associated with lower hospitalization risk and improved cognitive function in recurrent hepatic encephalopathy. Gastroenterology, 152(5), S906.

Academic Publication

2017

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial external link icon Opens a new window

Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., ... & Williams, R. (2017). Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Hepatology.

Academic Publication

2017

Classifying Fecal Microbiota Transplantation Failure: An Observational Study Examining Timing and Characteristics of Fecal Microbiota Transplantation Failures. external link icon Opens a new window

Allegretti, J. R., Phelps, E., Allegretti, A., Xu, H., Fischer, M., & Kassam, Z. (2017). Classifying Fecal Microbiota Transplantation Failure: An Observational Study Examining Timing and Characteristics of Fecal Microbiota Transplantation Failures. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association.

Academic Publication

2017

Early Antibiotic Use After Fecal Microbiota Transplantation Increases Risk of Treatment Failure external link icon Opens a new window

Allegretti, J. R., Kao, D., Sitko, J., Fischer, M., & Kassam, Z. (2017). Early Antibiotic Use After Fecal Microbiota Transplantation Increases Risk of Treatment Failure. Clinical Infectious Diseases, 66(1), 134-135.

Academic Publication

2017

The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present and Future external link icon Opens a new window

Allegretti, J., Eysenbach, L. M., El-Nachef, N., Fischer, M., Kelly, C., & Kassam, Z. (2017). The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present, and Future. Inflammatory bowel diseases, 23(10), 1710-1717.

Academic Publication

2018

Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation external link icon Opens a new window

Smillie, C. S., Sauk, J., Gevers, D., Friedman, J., Sung, J., Youngster, I., ... & Allegretti, J. R. (2018). Strain tracking reveals the determinants of bacterial engraftment in the human gut following fecal microbiota transplantation. Cell host & microbe, 23(2), 229-240.

Academic Publication

2018

Scaling Pediatric Access to Fecal Microbiota Transplantation in the United States: A Time-Series Geospatial Analysis external link icon Opens a new window

Panchal, P., Kahn, S., Zellmer, C., Kassam, Z., Osman, M., Allegretti, J., ... & NASPGHAN FMT Special Interest Group. (2018, November). 533. Scaling Pediatric Access to Fecal Microbiota Transplantation in the United States: A Time-Series Geospatial Analysis. Open Forum Infectious Diseases (Vol. 5, No. suppl_1, pp. S197-S197). US: Oxford University Press.

Academic Publication

2018

Scaling Access to Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in the United States: A Geospatial Time-Series Analysis from 2013 to 2017 external link icon Opens a new window

Panchal, P., Elliott, R. J., Budree, S., Osman, M., Allegretti, J. R., Kelly, C. R., ... & Kassam, Z. (2018). 1010-Scaling Access to Fecal Microbiota Transplantation for Recurrent Clostridium Difficle Infection in the United States: A Geospatial Time-Series Analysis from 2013 to 2017. Gastroenterology, 154(6), S-190.

Academic Publication

2018

Scaling Safe Access to Fecal Microbiota Transplantation: Past, Present, and Future external link icon Opens a new window

Panchal, P., Budree, S., Scheeler, A., Medina, G., Seng, M., Wong, W. F., & Eliot, R. (2018). Scaling Safe Access to Fecal Microbiota Transplantation: Past, Present, and Future. Current Gastroenterology Reports, 20(4), 14.

Academic Publication

2018

Early Results of Fecal Microbial Transplantation Protocol Implementation at a Community-based University Hospital external link icon Opens a new window

Duarte-Chavez, R., Wojda, T. R., Zanders, T. B., Geme, B., Fioravanti, G., & Stawicki, S. P. (2018). Early results of fecal microbial transplantation protocol implementation at a community-based university hospital. Journal of global infectious diseases, 10(2), 47.

Academic Publication

2018

Do Clinical Factors Affect Microbial Engraftment After Fecal Microbiota Transplantation in Recurrent Clostridium difficile Infection? external link icon Opens a new window

Budree, S., Osman, M., Panchal, P., Shu, E., Carrellas, M., Kassam, Z., & Allegretti, J. (2018, November). 618. Do Clinical Factors Affect Microbial Engraftment After Fecal Microbiota Transplantation in Recurrent Clostridium difficile Infection?. Open Forum Infectious Diseases (Vol. 5, No. suppl_1, pp. S225-S226). US: Oxford University Press.

Academic Publication

2018

Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection external link icon Opens a new window

Brown, J. R. M., Flemer, B., Joyce, S. A., Zulquernain, A., Sheehan, D., Shanahan, F., & O’Toole, P. W. (2018). Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection. BMC Gastroenterology, 18(1), 131.

Academic Publication

2018

Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality. external link icon Opens a new window

Barnes, D., Ng, K., Smits, S., Sonnenburg, J., Kassam, Z., & Park, K. T. (2018). Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality. Journal of pediatric gastroenterology and nutrition.

Academic Publication

2018

The 5D framework: a clinical primer for fecal microbiota transplantation to treat Clostridium difficile infection external link icon Opens a new window

Allegretti, J. R., Kassam, Z., Osman, M., Budree, S., Fischer, M., & Kelly, C. R. (2018). The 5D framework: a clinical primer for fecal microbiota transplantation to treat Clostridium difficile infection. Gastrointestinal endoscopy, 87(1), 18-29.

Academic Publication

2018

Small Intestinal Bacterial Overgrowth: Should Screening Be Included in the Pre-fecal Microbiota Transplantation Evaluation? external link icon Opens a new window

Allegretti, J. R., Kassam, Z., & Chan, W. W. (2018). Small Intestinal Bacterial Overgrowth: Should Screening Be Included in the Pre-fecal Microbiota Transplantation Evaluation?. Digestive diseases and sciences, 63(1), 193-197.

Academic Publication

2019

Outcomes of a Multidisciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis external link icon Opens a new window

Shin, J., Chaplin, A., Hays, R., Kolling, G., Vance, S., & Guerrant, R. et al. (2019). Outcomes of a Multidisciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis. Journal Of Clinical Medicine, 8(7), 1036. doi:10.3390/jcm8071036

Academic Publication

2019

Where Stool is a Drug: International Approaches to Regulating the use of Fecal Microbiota for Transplantation external link icon Opens a new window

Scheeler A. Where Stool is a Drug: International Approaches to Regulating the use of Fecal Microbiota for Transplantation. J Law Med Ethics. 2019 Dec;47(4):524-540. doi: 10.1177/1073110519897729. PMID: 31957572.

Academic Publication

2019

Nuts and Bolts of Fecal Microbiota Transplantation external link icon Opens a new window

Krajicek, E., Fischer, M., Allegretti, J., & Kelly, C. (2019). Nuts and Bolts of Fecal Microbiota Transplantation. Clinical Gastroenterology And Hepatology, 17(2), 345-352. doi:10.1016/j.cgh.2018.09.029

Academic Publication

2019

Risk Factors for Gastrointestinal Symptoms Following Successful Eradication of Clostridium difficile by Fecal Microbiota Transplantation (FMT) external link icon Opens a new window

Allegretti, J.R., Kassam, Z., Fischer, M., Kelly, C., & Chan W.W. (2019). Risk Factors for Gastrointestinal Symptoms Following Successful Eradication of Clostridium difficile by Fecal Microbiota Transplantation (FMT). Journal Of Clinical Gastroenterology, 1. doi:10.1097/mcg.0000000000001194

Academic Publication

2019

Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis? external link icon Opens a new window

Allegretti, J., Kao, D., Phelps, E., Roach, B., Smith, J., & Ganapini, V. et al. (2019). Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis?. Digestive Diseases And Sciences. doi:10.1007/s10620-018-5450-4

Academic Publication

2019

The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications external link icon Opens a new window

Allegretti, J., Mullish, B., Kelly, C., & Fischer, M. (2019). The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications. The Lancet, 394(10196), 420-431. doi:10.1016/s0140-6736(19)31266-8

Academic Publication

2019

Donor Screening for Fecal Microbiota Transplantation external link icon Opens a new window

Kassam Z, et al. (2019). Donor Screening for Fecal Microbiota Transplantation. NEJM. doi: 10.1056/NEJMc1913670.

Academic Publication

2020

Shiga toxin-producing E. coli transmission via fecal microbiota transplant external link icon Opens a new window

Zellmer, C., Sater, M., Huntley, M., Osman, M., Olesen, S., & Ramakrishna, B. (2020). Shiga toxin-producing E. coli transmission via fecal microbiota transplant. Clinical Infectious Diseases. doi: 10.1093/cid/ciaa1486

Academic Publication

2020

Power calculations for detecting differences in efficacy of fecal microbiota donors external link icon Opens a new window

Olesen SW. Power calculations for detecting differences in efficacy of fecal microbiota donors. Contemp Clin Trials Commun. 2020 Nov 6;20:100674. doi: 10.1016/j.conctc.2020.100674. PMID: 33241161; PMCID: PMC7672275.

Academic Publication

2020

Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection external link icon Opens a new window

Allegretti, J., Mehta, S., Kassam, Z., Kelly, C., Kao, D., Xu, H., & Fischer, M. (2020). Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection. Digestive Diseases And Sciences. doi:10.1007/s10620-020-06198-2

Academic Publication

2020

Ulcerative Proctitis in a Patient With a History of Fecal Microbiota Transplant for Clostridioides difficile Infection external link icon Opens a new window

Massaro, M., Vansia, J., & McGill, S. (2020). Ulcerative Proctitis in a Patient With a History of Fecal Microbiota Transplant for Clostridioides difficile Infection. ACG Case Reports Journal, 7(4), e00364. doi: 10.14309/crj.0000000000000364

Academic Publication

2020

Systematic review: the global incidence of faecal microbiota transplantation-related adverse events from 2000 to 2020 external link icon Opens a new window

Marcella C, Cui B, Kelly CR, Ianiro G, Cammarota G, Zhang F. Systematic review: the global incidence of faecal microbiota transplantation-related adverse events from 2000 to 2020. Aliment Pharmacol Ther. 2020 Nov 7. doi: 10.1111/apt.16148. Epub ahead of print. PMID: 33159374.

Academic Publication

2020

Fecal Microbiota Transplants Annually and Their Positive Clinical Impact external link icon Opens a new window

Mamoon, Lamia and Olesen, Scott W. Fecal Microbiota Transplants Annually and Their Positive Clinical Impact, Clinical and Translational Gastroenterology: November 2020 - Volume 11 - Issue 11 - p e00247 doi: 10.14309/ctg.0000000000000247

Academic Publication

2020

Monitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment external link icon Opens a new window

Kelly, C., Laine, L., & Wu, G. (2020). Monitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment. Gastroenterology, 159(6), 2004-2006. doi: 10.1053/j.gastro.2020.08.039

Academic Publication

2020

Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel external link icon Opens a new window

Ianiro, G., Mullish, B., Kelly, C., Sokol, H., Kassam, Z., & Ng, S. et al. (2020). Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel. The Lancet Gastroenterology & Hepatology. doi:10.1016/s2468-1253(20)30082-0

Academic Publication

2020

Long-Term Outcomes Following Multiply Recurrent Clostridioides Difficile Infection and Fecal Microbiota Transplantation external link icon Opens a new window

Dawwas G, Brensinger CM, Vajravelu RK, Wu Q, Kelly CR, Laine L, Wu GD, Lewis JD. Long-Term Outcomes Following Multiply Recurrent Clostridioides Difficile Infection and Fecal Microbiota Transplantation. Clin Gastroenterol Hepatol. 2020 Dec 8:S1542-3565(20)31642-6. doi: 10.1016/j.cgh.2020.12.004. Epub ahead of print. PMID: 33307184

Academic Publication

2020

Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation external link icon Opens a new window

Jessica R. Allegretti, Ryan J. Elliott, Alim Ladha, Mary Njenga, Kurt Warren, Kelsey O’Brien, Shrish Budree, Majdi Osman, Monika Fischer, Colleen R. Kelly & Zain Kassam (2020): Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation. Gut Microbes, DOI: 10.1080/19490976.2020.1768777

Academic Publication

2021

Fecal Microbiota Transplantation: The Evolving Risk Landscape external link icon Opens a new window

Gupta S, Mullish BH, Allegretti JR. Fecal Microbiota Transplantation: The Evolving Risk Landscape. Am J Gastroenterol. 2021 Feb 5. doi: 10.14309/ajg.0000000000001075. Epub ahead of print. PMID: 33606488.

Academic Publication

2021

Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children external link icon Opens a new window

Nicholson MR, Mitchell PD, Alexander E, Ballal S, Bartlett M, Becker P, Davidovics Z, Docktor M, Dole M, Felix G, Gisser J, Hourigan SK, Jensen MK, Kaplan JL, Kelsen J, Kennedy M, Khanna S, Knackstedt E, Leier M, Lewis J, Lodarek A, Michail S, Oliva-Hemker M, Patton T, Queliza K, Russell GH, Singh N, Solomon A, Suskind DL, Werlin S, Kellermayer R, Kahn SA. Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children. Clin Gastroenterol Hepatol. 2020 Mar;18(3):612-619.e1. doi: 10.1016/j.cgh.2019.04.037. Epub 2019 Apr 19. PMID: 31009795; PMCID: PMC7549313.

Academic Publication

2021

Current Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children external link icon Opens a new window

Nicholson, M., Hourigan, S., Conrad, M., Goyal, A., Jensen, K., & Kelsen, J. et al. (2021). Current Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children. American Journal Of Gastroenterology, Publish Ahead of Print. doi: 10.14309/ajg.0000000000001350

Academic Publication

2021

Fecal Microbiota Transplantation Is Safe for Clostridiodies difficile Infection in Patients with Solid Tumors external link icon Opens a new window

Mendelsohn, R., Kaltsas, A., King, S., Hwang, C., Kassam, Z., & Abend, A. et al. (2021). Fecal Microbiota Transplantation Is Safe for Clostridiodies difficile Infection in Patients with Solid Tumors Undergoing Chemotherapy. Digestive Diseases And Sciences. doi: 10.1007/s10620-021-07024-z

Academic Publication

2021

Fecal Microbiota Transplantation for Recurrent C difficile Infection During the COVID-19 Pandemic external link icon Opens a new window

Khanna, S., Tande, A., Rubin, D., Khoruts, A., Kahn, S., & Pardi, D. (2021). Fecal Microbiota Transplantation for Recurrent C difficile Infection During the COVID-19 Pandemic. Mayo Clinic Proceedings, 96(6), 1418-1425. doi: 10.1016/j.mayocp.2021.04.005

Academic Publication

2021

Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry external link icon Opens a new window

Kelly, C., Yen, E., Grinspan, A., Kahn, S., Atreja, A., & Lewis, J. et al. (2021). Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology, 160(1), 183-192.e3. doi: 10.1053/j.gastro.2020.09.038

Academic Publication

2021

Updates and Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children external link icon Opens a new window

Hourigan, S., Nicholson, M., Kahn, S., & Kellermayer, R. (2021). Updates and Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children. Journal Of Pediatric Gastroenterology & Nutrition, Publish Ahead of Print. doi: 10.1097/mpg.0000000000003229

Academic Publication

2021

Oral Fecal Microbiota Transplant Capsules Are Safe and Effective for Recurrent Clostridioides difficile Infection external link icon Opens a new window

Du, C., Luo, Y., Walsh, S., & Grinspan, A. (2021). Oral Fecal Microbiota Transplant Capsules Are Safe and Effective for Recurrent Clostridioides difficile Infection. Journal Of Clinical Gastroenterology, 55(4), 300-308. doi: 10.1097/mcg.0000000000001495

Academic Publication

2021

Stool Banking for Fecal Microbiota Transplantation: Methods and Operations at a Large Stool Bank external link icon Opens a new window

Chen, J., Zaman, A., Ramakrishna, B., & Olesen, S. (2021). Stool Banking for Fecal Microbiota Transplantation: Methods and Operations at a Large Stool Bank. Frontiers In Cellular And Infection Microbiology, 11. doi: 10.3389/fcimb.2021.622949

Academic Publication

2022

Pilot study of autologous fecal microbiota transplants in nursing home residents: Feasibility and safety external link icon Opens a new window

Liu CK, Seo J, Pravodelov V, Frazier S, Guy M, Concilio K, Lau-Ng R, Brandeis G, Watson J, van der Velde J, Olesen SW, Budree S, Njenga M, Kassam Z, Osman M. Pilot study of autologous fecal microbiota transplants in nursing home residents: Feasibility and safety. Contemp Clin Trials Commun. 2022 Mar 7;27:100906. doi: 10.1016/j.conctc.2022.100906. PMID: 35299780; PMCID: PMC8921299

Academic Publication

2014

Review of the Emerging Treatment of Clostridium difficile Infection with Fecal Microbiota Transplantation and Insights into Future Challenges external link icon Opens a new window

Kassam, Z., Lee, C., & Hunt, R. (2014). Review of the Emerging Treatment of Clostridium difficile Infection with Fecal Microbiota Transplantation and Insights into Future Challenges. Clinics In Laboratory Medicine, 34(4), 787-798. doi:10.1016/j.cll.2014.08.007

Academic Publication

2016

Safety and Efficacy of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection From An International Public Stool Bank: Results From a 2050-Patient Multicenter Cohort external link icon Opens a new window

Osman, M., O'Brien, K., Stoltzner, Z., Ling, K., Koelsch, E., & Dubois, N. et al. (2016). Safety and Efficacy of Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection From An International Public Stool Bank: Results From a 2050-Patient Multicenter Cohort. Open Forum Infectious Diseases, 3(suppl_1). doi:10.1093/ofid/ofw172.1668

Academic Publication

2016

Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease external link icon Opens a new window

Fischer, M., Kao, D., Kelly, C., Kuchipudi, A., Jafri, S. M., Blumenkehl, M., ... & Cook, G. (2016). Fecal microbiota transplantation is safe and efficacious for recurrent or refractory Clostridium difficile infection in patients with inflammatory bowel disease. Inflammatory bowel diseases, 22(10), 2402-2409.

Academic Publication

2017

Faecal microbiota transplantation for Clostridium difficile infection: a multicentre study of non-responders external link icon Opens a new window

Razik, R., Osman, M., Lieberman, A., Allegretti, J. R., & Kassam, Z. (2017). Faecal microbiota transplantation for Clostridium difficile infection: a multicentre study of non-responders. Med J Aust; 207 (4): 159-160.

Academic Publication

2017

Pediatric access to fecal microbiota transplantation for recurrent Clostridium difficile Infection in the United States and the impact of stool banks: a geospatial analysis external link icon Opens a new window

Panchal, P., Budree, S., Tu, E., Kahn, S. A., Allegretti, J. R., Fischer, M., ... & Osman, M. (2017). Pediatric Access to Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection in the United States and the Impact of Stool Banks: A Geospatial Analysis. Gastroenterology, 152(5), S849-S850.

Academic Publication

2017

Fecal microbiota transplantation is safe and effective for the treatment of Clostridium difficile infection in solid organ transplant recipients external link icon Opens a new window

Piceno, Y. M., El-Nachef, N., Kassam, Z., Smith, M., Lynch, K., Zydek, M., ... & Lynch, S. (2017). Fecal Microbiota Transplantation Differentially Influences the Gut Microbiota of Clostridium Difficile Infection and Ileal Pouch Anal Anastomosis Patients. Gastroenterology, 152(5), S1006.

Academic Publication

2017

Fecal microbiota transplantation differentially influences the gut microbiota of Clostridium difficile infection and ileal pouch anal anastomosis patients external link icon Opens a new window

Piceno, Y. M., El-Nachef, N., Kassam, Z., Smith, M., Lynch, K., Zydek, M., ... & Lynch, S. (2017). Fecal Microbiota Transplantation Differentially Influences the Gut Microbiota of Clostridium Difficile Infection and Ileal Pouch Anal Anastomosis Patients. Gastroenterology, 152(5), S1006.

Academic Publication

2017

A Surgical Clostridium-associated Risk of Death Score Predicts Mortality after Colectomy for Clostridium difficile external link icon Opens a new window

Kulaylat, A. S., Kassam, Z., Hollenbeak, C. S., & Stewart Sr, D. B. (2017). A Surgical Clostridium-Associated Risk of Death Score Predicts Mortality After Colectomy for Clostridium difficile. Diseases of the Colon & Rectum, 60(12), 1285-1290.

Academic Publication

2017

Should we recommend anti-Clostridium difficile antibiotic or probiotic prophylaxis? Risk of Clostridium difficile infection with systemic antimicrobial therapy following successful fecal microbiota transplant external link icon Opens a new window

Fischer, M., Kao, D. H., Phelps, E. L., Smith, J. D., Roach, B., Kassam, Z., ... & Allegretti, J. R. (2017). Should we Recommend Anti-Clostridium Difficile Antibiotic or Probiotic Prophylaxis?: Risk of Clostridium Difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant. Gastroenterology, 152(5), S1005.

Academic Publication

2017

Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease external link icon Opens a new window

Fischer, M., Bittar, M., Papa, E., Kassam, Z., & Smith, M. (2017). Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease. Gut microbes, 8(3), 205-207.

Academic Publication

2017

Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors external link icon Opens a new window

Budree, S., Wong, W. F., Tu, E., Rao, S., Allegretti, J. R., Fischer, M., ... & Kassam, Z. (2017). Do Specific Bacteria Drive Clinical Cure in Fecal Microbiota Transplantation for Clostridium Difficile Infection?: Clinical, Microbial and Metabolomic Characterization of Universal FMT Donors. Gastroenterology, 152(5), S349.

Academic Publication

2017

The association of stool donor diet on microbial profile and clinical outcomes of fecal microbiota transplantation in clostridium difficile infection external link icon Opens a new window

Budree, S., Tu, E., Leith, T., Allegretti, J. R., Rao, S., Day, R., ... & Osman, M. (2017). The Association of Stool Donor Diet on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630-S631.

Academic Publication

2017

The association of donor stool consistency by Bristol stool scale on microbial profile and clinical outcomes of fecal microbiota transplantation in Clostridium difficile infection external link icon Opens a new window

Budree, S., Rao, S., Allegretti, J. R., Fischer, M., Kelly, C. R., Smith, M., ... & Kassam, Z. (2017). The Association of Donor Stool Consistency by Bristol Stool Scale on Microbial Profile and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S630.

Academic Publication

2017

Donor stool processing time: the effect on the intestinal microbiome and clinical outcomes of fecal microbiota transplantation in Clostridium difficile Infection external link icon Opens a new window

Budree, S., Elliott, R. J., Rao, S., Njenga, M., Ladha, A., Allegretti, J. R., ... & Kassam, Z. (2017). Donor Stool Processing Time: The Effect on the Intestinal Microbiome and Clinical Outcomes of Fecal Microbiota Transplantation in Clostridium Difficile Infection. Gastroenterology, 152(5), S1006.

Academic Publication

2017

Asymptomatic Clostridium difficile carriage rate post-fecal microbiota transplant is low: a prospective clinical and stool assessment. external link icon Opens a new window

Allegretti, J. R., Allegretti, A. S., Phelps, E., Xu, H., Kassam, Z., & Fischer, M. (2017). Asymptomatic Clostridium difficile carriage rate post-fecal microbiota transplant is low: a prospective clinical and stool assessment. Clinical Microbiology and Infection

Academic Publication

2018

Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience external link icon Opens a new window

Cheng, Y. W., Phelps E., Ganapini V., Khan N., Ouyang, F., Xu H., … & Fischer M. (2018) Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience. American Journal of Transplantation, 10.1111/ajt.15058.

Academic Publication

2018

Do Clinical Factors Affect Microbial Engraftment After Fecal Microbiota Transplantation in Recurrent Clostridium difficile Infection? external link icon Opens a new window

Budree, S., Osman, M., Panchal, P., Shu, E., Carrellas, M., Kassam, Z., & Allegretti, J. (2018, November). 618. Do Clinical Factors Affect Microbial Engraftment After Fecal Microbiota Transplantation in Recurrent Clostridium difficile Infection?. Open Forum Infectious Diseases (Vol. 5, No. suppl_1, pp. S225-S226). US: Oxford University Press.

Academic Publication

2018

Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection external link icon Opens a new window

Brown, J. R. M., Flemer, B., Joyce, S. A., Zulquernain, A., Sheehan, D., Shanahan, F., & O’Toole, P. W. (2018). Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection. BMC Gastroenterology, 18(1), 131.

Academic Publication

2018

Frail Heart, Friable Colon: A Case Report of Fecal Microbiota Transplant for Refractory Clostridium difficile Infection in a Patient with Recent Trans-Catheter Aortic Valve Replacement external link icon Opens a new window

Bhanvadia, A. (2018) Frail Heart, Friable Colon: A Case Report of Fecal Microbiota Transplant for Refractory Clostridium difficile Infection in a Patient with Recent Trans-Catheter Aortic Valve Replacement. J Inflam Bowel Dis & Discord 3(1): 124.

Academic Publication

2018

The 5D framework: a clinical primer for fecal microbiota transplantation to treat Clostridium difficile infection external link icon Opens a new window

Allegretti, J. R., Kassam, Z., Osman, M., Budree, S., Fischer, M., & Kelly, C. R. (2018). The 5D framework: a clinical primer for fecal microbiota transplantation to treat Clostridium difficile infection. Gastrointestinal endoscopy, 87(1), 18-29.

Academic Publication

2018

Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose external link icon Opens a new window

Allegretti, J. R., Fischer, M., Sashidar V. S., Bohm, M. E., Fadda, H. M., Ranmal, S. R., Budree, S., Basit, A. W., Glettif, D. L., de la Serna, E. L., Gentile, A., Gerardin, Y., Timberlake, S. T., Sadovsky, R., Smith, M., Kassam, Z. (2018). Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose. Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-018-5396-6.

Academic Publication

2019

Faecal microbiota transplant decreases mortality in severe and fulminant Clostridioides difficile infection in critically ill patients external link icon Opens a new window

Tixier, E., Verheyen, E., Ungaro, R., & Grinspan, A. (2019). Faecal microbiota transplant decreases mortality in severe and fulminant Clostridioides difficile infection in critically ill patients. Alimentary Pharmacology & Therapeutics. doi:10.1111/apt.15526

Academic Publication

2019

Outcomes of a Multidisciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis external link icon Opens a new window

Shin, J., Chaplin, A., Hays, R., Kolling, G., Vance, S., & Guerrant, R. et al. (2019). Outcomes of a Multidisciplinary Clinic in Evaluating Recurrent Clostridioides difficile Infection Patients for Fecal Microbiota Transplant: A Retrospective Cohort Analysis. Journal Of Clinical Medicine, 8(7), 1036. doi:10.3390/jcm8071036

Academic Publication

2019

Patients Eligible for Trials of Microbe-based Therapeutics do not Represent the Population With Recurrent Clostridioides difficile Infection external link icon Opens a new window

Kelly, C., Fischer, M., Grinspan, A., & Allegretti, J. (2019). Patients Eligible for Trials of Microbe-based Therapeutics do not Represent the Population With Recurrent Clostridioides difficile Infection. Clinical Gastroenterology And Hepatology. doi:10.1016/j.cgh.2019.06.034

Academic Publication

2019

Bezlotoxumab use as adjunctive therapy with the third fecal microbiota transplant in refractory recurrent Clostridium difficilecolitis; a case report and concise literature review external link icon Opens a new window

Kaako, A., Al-Amer, M., & Abdeen, Y. (2019). Bezlotoxumab use as adjunctive therapy with the third fecal microbiota transplant in refractory recurrent Clostridium difficile colitis; a case report and concise literature review. Anaerobe, 55, 112-116. doi:10.1016/j.anaerobe.2018.11.010

Academic Publication

2019

Treatment of Severe and Fulminnant Clostridioides difficile Infection external link icon Opens a new window

Cheng, Y., & Fischer, M. (2019). Treatment of Severe and Fulminnant Clostridioides difficile Infection. Current Treatment Options In Gastroenterology. doi:10.1007/s11938-019-00262-1

Academic Publication

2019

Clinical Predictors of Recurrence After Primary Clostridioides difficile Infection: A Prospective Cohort Study external link icon Opens a new window

Allegretti, J., Marcus, J., Storm, M., Sitko, J., Kennedy, K., Gerber, G., & Bry, L. (2019). Clinical Predictors of Recurrence After Primary Clostridioides difficile Infection: A Prospective Cohort Study. Digestive Diseases And Sciences. doi:10.1007/s10620-019-05900-3

Academic Publication

2019

Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis? external link icon Opens a new window

Allegretti, J., Kao, D., Phelps, E., Roach, B., Smith, J., & Ganapini, V. et al. (2019). Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis?. Digestive Diseases And Sciences. doi:10.1007/s10620-018-5450-4

Academic Publication

2019

Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Lose Dose external link icon Opens a new window

Allegretti, J., Fischer, M., Sagi, S., Bohm, M., Fadda, H., & Ranmal, S. et al. (2018). Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Lose Dose. Digestive Diseases And Sciences, 64(6), 1672-1678. doi:10.1007/s10620-018-5396-6

Academic Publication

2020

Diagnosis and Treatment of Clostridioides (Clostridium) difficile Infection in Adults in 2020 external link icon Opens a new window

Rao, K., & Malani, P. (2020). Diagnosis and Treatment of Clostridioides (Clostridium) difficile Infection in Adults in 2020. JAMA, 323(14), 1403. doi: 10.1001/jama.2019.3849

Academic Publication

2020

Long-Term Efficacy and Safety of Fecal Microbiota Transplantation for Treatment of Recurrent Clostridioides difficile Infection external link icon Opens a new window

Perler, B., Chen, B., Phelps, E., Allegretti, J., Fischer, M., & Ganapini, V. et al. (2020). Long-Term Efficacy and Safety of Fecal Microbiota Transplantation for Treatment of Recurrent Clostridioides difficile Infection. Journal Of Clinical Gastroenterology, 1. doi:10.1097/mcg.0000000000001281

Academic Publication

2020

Fecal microbiota transplantation "donor effects" are not clinically relevant for Clostridioides difficile infection external link icon Opens a new window

Olesen SW. Fecal microbiota transplantation "donor effects" are not clinically relevant for Clostridioides difficile infection. Gastroenterology. 2020 Dec 30:S0016-5085(20)35620-1. doi: 10.1053/j.gastro.2020.12.057. Epub ahead of print. PMID: 33387515.

Academic Publication

2020

Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites external link icon Opens a new window

Martinez-Gili, L., McDonald, J., Liu, Z., Kao, D., Allegretti, J., & Monaghan, T. et al. (2020). Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites. Gut Microbes, 12(1), 1810531. doi: 10.1080/19490976.2020.1810531

Academic Publication

2020

Fecal Microbiota Transplants Annually and Their Positive Clinical Impact external link icon Opens a new window

Mamoon, Lamia and Olesen, Scott W. Fecal Microbiota Transplants Annually and Their Positive Clinical Impact, Clinical and Translational Gastroenterology: November 2020 - Volume 11 - Issue 11 - p e00247 doi: 10.14309/ctg.0000000000000247

Academic Publication

2020

Fecal Microbiota Transplant Decreases Mortality in Patients with Refractory Severe or Fulminant Clostridioides difficile Infection external link icon Opens a new window

Cheng, Y., Phelps, E., Nemes, S., Rogers, N., Sagi, S., & Bohm, M. et al. (2020). Fecal Microbiota Transplant Decreases Mortality in Patients with Refractory Severe or Fulminant Clostridioides difficile Infection. Clinical Gastroenterology And Hepatology. doi:10.1016/j.cgh.2019.12.029

Academic Publication

2020

Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection external link icon Opens a new window

Allegretti, J., Kelly, C., Grinspan, A., Mullish, B., Kassam, Z., & Fischer, M. (2020). Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection. Gastroenterology, 159(5), 1982-1984. doi: 10.1053/j.gastro.2020.07.045

Academic Publication

2020

Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation external link icon Opens a new window

Jessica R. Allegretti, Ryan J. Elliott, Alim Ladha, Mary Njenga, Kurt Warren, Kelsey O’Brien, Shrish Budree, Majdi Osman, Monika Fischer, Colleen R. Kelly & Zain Kassam (2020): Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation. Gut Microbes, DOI: 10.1080/19490976.2020.1768777

Academic Publication

2020

Treatment of Recurrent Clostridium difficile Infection in an Immunocompromised Patient with Severe Neutropenia Not Responding to Standard Therapy external link icon Opens a new window

AlQahtani, H., Baloch, S., & Tabb, D. (2020). Treatment of Recurrent Clostridium difficile Infection in an Immunocompromised Patient with Severe Neutropenia Not Responding to Standard Therapy. Case Reports In Infectious Diseases, 2020, 1-4. doi:10.1155/2020/3089023

Academic Publication

2021

Systematic Review with Meta-Analysis: Fecal Microbiota Transplantation for Severe or Fulminant Clostridioides difficile external link icon Opens a new window

Tixier EN, Verheyen E, Luo Y, Grinspan LT, Du CH, Ungaro RC, Walsh S, Grinspan AM. Systematic Review with Meta-Analysis: Fecal Microbiota Transplantation for Severe or Fulminant Clostridioides difficile. Dig Dis Sci. 2021 Mar 22. doi: 10.1007/s10620-021-06908-4. Epub ahead of print. PMID: 33748913.

Academic Publication

2021

Fecal Microbiota Transplantation for Severe or Fulminant Clostridioides difficile Infection external link icon Opens a new window

Song YN, Yang DY, Veldhuyzen van Zanten S, Wong K, McArthur E, Song CZ, Ianiro G, Cammarota G, Kelly C, Fischer M, Russell L, Kao D. Fecal Microbiota Transplantation for Severe or Fulminant Clostridioides difficile Infection: Systematic Review and Meta-analysis. J Can Assoc Gastroenterol. 2021 Jul 23;5(1):e1-e11. doi: 10.1093/jcag/gwab023. PMID: 35118227; PMCID: PMC8806043.

Academic Publication

2021

Management of Severe and Severe/Complicated Clostridoides difficile Infection using Sequential Fecal Microbiota Transplant by Retention Enema external link icon Opens a new window

Rupawala AH, Gachette D, Bakhit M, Jimoh L, Kelly CR. Management of Severe and Severe/Complicated Clostridoides difficile Infection using Sequential Fecal Microbiota Transplant by Retention Enema. Clin Infect Dis. 2021 Jan 21:ciab041. doi: 10.1093/cid/ciab041. Epub ahead of print. PMID: 33476379.

Academic Publication

2021

Pediatric Fecal Microbiota Transplantation in Recurrent Clostridioides Difficile external link icon Opens a new window

Parnell JM, Nicholson MR, Kellermayer R, Kahn SA. Pediatric Fecal Microbiota Transplantation in Recurrent Clostridioides Difficile. Pediatr Ann. 2021 Dec;50(12):e515-e521. doi: 10.3928/19382359-20211111-01. Epub 2021 Dec 1. PMID: 34889135.

Academic Publication

2021

The contribution of bile acid metabolism to the pathogenesis of Clostridioides difficile infection external link icon Opens a new window

Mullish, B., & Allegretti, J. (2021). The contribution of bile acid metabolism to the pathogenesis of Clostridioides difficile infection. Therapeutic Advances In Gastroenterology, 14, 175628482110177. doi: 10.1177/17562848211017725

Academic Publication

2021

Hospital-onset Clostridioides difficile infections during the COVID-19 pandemic external link icon Opens a new window

Luo Y, Grinspan LT, Fu Y, Adams-Sommer V, Willey DK, Patel G, Grinspan AM. Hospital-onset Clostridioides difficile infections during the COVID-19 pandemic. Infect Control Hosp Epidemiol. 2021 Sep;42(9):1165-1166. doi: 10.1017/ice.2020.1223. Epub 2020 Sep 23. PMID: 32962772; PMCID: PMC7545245.

Academic Publication

2021

ACG Clinical Guidelines external link icon Opens a new window

Kelly, C., Fischer, M., Allegretti, J., LaPlante, K., Stewart, D., & Limketkai, B. et al. (2021). ACG Clinical Guidelines. American Journal Of Gastroenterology, Publish Ahead of Print. doi: 10.14309/ajg.0000000000001278

Academic Publication

2021

Cost-effectiveness analysis of sequential fecal microbiota transplantation for fulminant Clostridioides difficile infection external link icon Opens a new window

Gupta S, Zhu J, McCarty TR, Pruce J, Kassam Z, Kelly C, Fischer M, Allegretti JR. Cost-effectiveness analysis of sequential fecal microbiota transplantation for fulminant Clostridioides difficile infection. J Gastroenterol Hepatol. 2021 Sep;36(9):2432-2440. doi: 10.1111/jgh.15483. Epub 2021 Mar 17. PMID: 33682170.

Academic Publication

2021

FMT for Severe C. difficile Infection: If at First You Do No Harm, the Second Time’s a Charm external link icon Opens a new window

Grinspan, A. (2020). FMT for Severe C. difficile Infection: If at First You Do No Harm, the Second Time’s a Charm. Digestive Diseases And Sciences, 66(1), 5-6. doi: 10.1007/s10620-020-06309-z

Academic Publication

2021

Heterogeneity of Randomized Controlled Trials of Fecal Microbiota Transplantation in Recurrent Clostridioides difficile Infection external link icon Opens a new window

Feuerstadt P, Aroniadis OC, Svedlund FL, Garcia M, Stong L, Boules M, Khanna S. Heterogeneity of Randomized Controlled Trials of Fecal Microbiota Transplantation in Recurrent Clostridioides difficile Infection. Dig Dis Sci. 2021 Jul 18. doi: 10.1007/s10620-021-07141-9. Epub ahead of print. PMID: 34275058.

Academic Publication

2021

Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease: A Clinician's Dilemma external link icon Opens a new window

Conrad MA, Kelsen JR. Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease: A Clinician's Dilemma. J Pediatric Infect Dis Soc. 2021 Aug 3:piab069. doi: 10.1093/jpids/piab069. Epub ahead of print. PMID: 34343321.

Academic Publication

2021

Prevalence and impact of Clostridioides difficile infection among hospitalized patients with coranavirus disease 2019 external link icon Opens a new window

Allegretti, J., Nije, C., McClure, E., Redd, W., Wong, D., & Zhou, J. et al. (2021). Prevalence and impact of Clostridioides difficile infection among hospitalized patients with coranavirus disease 201 9. JGH Open, 5(5), 622-625. doi: 10.1002/jgh3.12497

Academic Publication

2021

Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection external link icon Opens a new window

Allegretti, J., Mehta, S., Kassam, Z., Kelly, C., Kao, D., Xu, H., & Fischer, M. (2020). Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection. Digestive Diseases And Sciences, 66(1), 213-217. doi: 10.1007/s10620-020-06198-2

Academic Publication

2022

Effectiveness and Safety of Fecal Microbiota Transplantation for Clostridioides Difficile Infection: Results From a 5344-Patient Cohort Study external link icon Opens a new window

Osman M, Budree S, Kelly CR, Panchal P, Allegretti JR, Kassam Z; OPENBIOME COLLABORATORS. Effectiveness and Safety of Fecal Microbiota Transplantation for Clostridioides Difficile Infection: Results From a 5344-Patient Cohort Study. Gastroenterology. 2022 Apr 7:S0016-5085(22)00351-1. doi: 10.1053/j.gastro.2022.03.051. Epub ahead of print. PMID: 35398345.

White Paper

July 2021

Efficacy of Fecal Microbiota Transplantation: Current Evidence on Clinical Cure for FMT for the Treatment of Recurrent C. difficile Infection

Controlled clinical trials and observational studies of Fecal Microbiota Transplantation (FMT) as a treatment for C. difficile infection (CDI) have reported cure rates ranging from 68%-100%. However, such trials and studies have varying definitions of recurrent C. difficile, use different FMT formulations and delivery methods, and treat different patient populations. This paper reviews important points to consider when extrapolating existing efficacy data to the unique situation of an individual patient.

White Paper

July 2021

Evaluating a Patient for FMT (For the Treatment of C. difficile)

Fecal Microbiota Transplantation (FMT) has been shown to treat 80-90% of C. difficile infections not responsive to antibiotic therapy in clinical trials and real-world settings. However, the utility of FMT depends on accurate CDI diagnosis and patient selection. As many as 25% of patients may be incorrectly referred for FMT. This paper covers the considerations when evaluating patients for FMT for the treatment of C. difficile.

White Paper

July 2021

Current Evidence on the Safety of Fecal Microbiota Transplantation (FMT) for C. difficile infection

In this paper, we provide an overview on the safety of FMT and important points to consider about the procedure. The perspectives presented here draw from the general safety of FMT sourced from universal stool banks (like OpenBiome) and hospital-based stool banks. This paper is aimed at physicians and healthcare professionals caring for patients being considered for FMT as well as patients themselves. The information reviewed here will help ensure that patients are fully informed of the safety profile of FMT and potential risks associated with the procedure before undergoing treatment.

White Paper

July 2021

Tracking Patient Outcomes and Adverse Events: Considerations for Pharmacovigilance

Detection and response to reported safety events is one of a stool bank's most important roles. A robust material tracking and pharmacovigilance program enables timely responses to suspected adverse events including safety measures to mitigate risk to patients receiving FMT at centers being supplied by the stool bank. This paper presents OpenBiome's material tracking and pharmacovigilance program as an example for surveilling patient responses to FMT.

White Paper

June 2021

When is an FMT Treatment Ready for Use? Health Monitoring and Material Release

Stool banking is a complex, multi-step process that includes screening and monitoring donor health as well as manufacturing fecal microbiota transplantation (FMT) preparations from donated stool. To help ensure that FMT preparations meet the stool bank’s quality and safety standards, a Quality Department reviews all information associated with an FMT preparation and its donor to verify that it is suitable for patient treatment. This paper outlines and discusses basic quality checks that FMT material should pass before it is released for clinical use.

White Paper

July 2021

From Stool Donation to FMT Preparation: The Logistics of FMT Manufacturing

Fecal microbiota transplantation (FMT) preparations comprise minimally processed stool that retain a broad fraction of the stool donor‚Äôs complete microbiome. In clinical trials and real-world settings, FMT has been shown to treat approximately 80% of antibiotic-resistant C. difficile infections and is the standard of treatment for recurrent C. difficile. This paper, using OpenBiome as an example, reviews important considerations for manufacturing FMT preparations including safety and operational measures. Note: Considerations for donor screening are covered separately in a white paper titled ‚ÄúClinical Considerations for Donor Selection‚ÄĚ

White Paper

July 2021

Clinical Considerations for Donor Screening

Evaluating the health of stool donors providing Fecal Microbiota Transplantation (FMT) material is a crucial and dynamic aspect of stool banking. Donor selection criteria may vary depending on multiple factors such as geography and patient population, and is continually being updated to reflect the latest understanding of FMT and the microbiome. This paper reviews clinical considerations underlying donor selection using OpenBiome’s screening criteria as an example.

White Paper

July 2021

How to Recruit and Engage Stool Donors

Stool banking depends on a pool of committed and healthy stool donors. Building a sustainable donor pool can be difficult as less than 3% of prospective donors may pass health screenings, necessitating a large recruitment effort. This paper reviews several considerations for recruiting stool donors including guidance on advertising, designing incentives, and maintaining clear communication with prospective and active donors.

White Paper

July 2021

Regulatory Oversight of Fecal Microbiota Transplantation (FMT): Consideration for Treating Clinicians

Fecal microbiota transplantation (FMT) follows a unique model of federal oversight in the United States. Although the U.S. Food and Drug Administration (FDA) considers FMT an investigational new drug, physicians may use FMT to treat patients with recurrent C. difficile infection under the agency‚Äôs policy of ‚Äúenforcement discretion.‚ÄĚ This document provides answers to frequently asked questions regarding the regulation of FMT, with an emphasis on the U.S. context.

White Paper

July 2021

Fecal Microbiota Transplantation: An Introduction to FMT, its History, and Therapeutic Potential

Fecal Microbiota Transplantation (FMT) has a long history dating back to 300 AD China but has only recently been adopted by Western medical practice. In this paper, we review the basic definition of Fecal Microbiota Transplantation, its development into the standard for care for recurrent C. difficile, and how it may advance medical care for other illnesses.

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